biostudies-literatureBeydoun MANational Institute on Aginge12275https://www.ebi.ac.uk/biostudies/studies/S-EPMC8924949biostudies-literatureUnknown8(1)<h4>Introduction</h4>Racial disparities in Alzheimer's disease (AD) and all-cause dementia (DEMENTIA) incidence may exist differentially among men and women, with unknown mechanisms.<h4>Methods</h4>A retrospective cohort study examining all-cause and AD dementia incidence was conducted linking Third National Health and Nutrition Examination Survey (NHANES III) to Centers for Medicare & Medicaid Services Medicare data over ≤26 years of follow-up (1988 to 2014). Cox regression and generalized structural equation models (GSEMs) were constructed among men and women ≥60 years of age at baseline (N = 4592). Outcomes included onset ages of all-cause and AD dementia, whereas the main exposures were race/ethnicity contrasts (RACE_ETHN). Potential mediators) included socio-economic status (SES), lifAlzheimer's & dementia (New York, N. Y.)Pathways explaining racial/ethnic disparities in incident all-cause and Alzheimer's disease dementia among older US men and women.PMC8924949Z01‐AG000513Weiss JEvans MKHossain SZonderman ABEl-Hajj ZWBeydoun MAFanelli-Kuczmarski MTBeydoun HAfalsePathways explaining racial/ethnic disparities in incident all-cause and Alzheimer's disease dementia among older US men and women.<h4>Introduction</h4>Racial disparities in Alzheimer's disease (AD) and all-cause dementia (DEMENTIA) incidence may exist differentially among men and women, with unknown mechanisms.<h4>Methods</h4>A retrospective cohort study examining all-cause and AD dementia incidence was conducted linking Third National Health and Nutrition Examination Survey (NHANES III) to Centers for Medicare & Medicaid Services Medicare data over ≤26 years of follow-up (1988 to 2014). Cox regression and generalized structural equation models (GSEMs) were constructed among men and women ≥60 years of age at baseline (N = 4592). Outcomes included onset ages of all-cause and AD dementia, whereas the main exposures were race/ethnicity contrasts (RACE_ETHN). Potential mediators) included socio-economic status (SES), lif2022-01-01T00:00:00Z20222025-04-25T22:57:19.08Z2025-04-06T09:15:29.342ZS-EPMC89249493531708110.1002/trc2.12275