biostudies-literatureUnknown22(1)Yan B<h4>Background</h4>The prognostic value of intratumor T regulatory cells (Tregs) in colorectal cancer (CRC) was previously reported, but the role of these cells in tumor draining lymph nodes (TDLNs) was less addressed.<h4>Methods</h4>A total of 150 CRC stages I-IV were retrospectively enrolled. Intratumor and TDLN Tregs were examined by immunohistochemical assay. The association of these cells was estimated by Pearson correlation. Survival analyses of subgroups were conducted by Kaplan-Meier curves, and the log-rank test and risk factors for survival were tested by the Cox proportional hazard model.<h4>Results</h4>High accumulation of Tregs in tumors was significant in patients with younger age and good histological grade, where enrichment of these cells in TDLNs was more apparent in thoseBMC gastroenterology122https://www.ebi.ac.uk/biostudies/studies/S-EPMC8925044biostudies-literatureCorrelation and prognostic implications of intratumor and tumor draining lymph node Foxp3⁺ T regulatory cells in colorectal cancer.PMC8925044Xiong JXue TXu MYe QLi FXiang JYan BWen WfalseCorrelation and prognostic implications of intratumor and tumor draining lymph node Foxp3⁺ T regulatory cells in colorectal cancer.<h4>Background</h4>The prognostic value of intratumor T regulatory cells (Tregs) in colorectal cancer (CRC) was previously reported, but the role of these cells in tumor draining lymph nodes (TDLNs) was less addressed.<h4>Methods</h4>A total of 150 CRC stages I-IV were retrospectively enrolled. Intratumor and TDLN Tregs were examined by immunohistochemical assay. The association of these cells was estimated by Pearson correlation. Survival analyses of subgroups were conducted by Kaplan-Meier curves, and the log-rank test and risk factors for survival were tested by the Cox proportional hazard model.<h4>Results</h4>High accumulation of Tregs in tumors was significant in patients with younger age and good histological grade, where enrichment of these cells in TDLNs was more apparent in those2022-01-01T00:00:00Z2022 Mar2025-04-26T10:16:53.033Z2025-04-06T13:16:55.081ZS-EPMC89250443529625710.1186/s12876-022-02205-0