{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["43(5)"],"submitter":["Naas T"],"pubmed_abstract":["A clinical isolate of Pseudomonas aeruginosa RP-1 produced the extended-spectrum beta-lactamase (ESBL) SHV-2a. Its gene was expressed from a composite promoter made of the -35 region derived from the left inverted repeat of IS26 and the -10 region from the blaSHV-2a promoter itself. The DNA sequences immediately surrounding blaSHV-2a were homologous to plasmid pMPA2a from Klebsiella pneumoniae KpZU-3, while further away and 3' to the blaSHV-2a gene, a sequence corresponding to the left end of Tn1721 was detected, thus indicating a likely enterobacterial origin of this ESBL gene."],"journal":["Antimicrobial agents and chemotherapy"],"pagination":["1281-4"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC89260"],"repository":["biostudies-literature"],"pubmed_title":["An SHV-derived extended-spectrum beta-lactamase in Pseudomonas aeruginosa."],"pmcid":["PMC89260"],"pubmed_authors":["Philippon L","Naas T","Ronco E","Nordmann P","Poirel L"],"additional_accession":[]},"is_claimable":false,"name":"An SHV-derived extended-spectrum beta-lactamase in Pseudomonas aeruginosa.","description":"A clinical isolate of Pseudomonas aeruginosa RP-1 produced the extended-spectrum beta-lactamase (ESBL) SHV-2a. Its gene was expressed from a composite promoter made of the -35 region derived from the left inverted repeat of IS26 and the -10 region from the blaSHV-2a promoter itself. The DNA sequences immediately surrounding blaSHV-2a were homologous to plasmid pMPA2a from Klebsiella pneumoniae KpZU-3, while further away and 3' to the blaSHV-2a gene, a sequence corresponding to the left end of Tn1721 was detected, thus indicating a likely enterobacterial origin of this ESBL gene.","dates":{"release":"1999-01-01T00:00:00Z","publication":"1999 May","modification":"2024-02-15T06:48:19.623Z","creation":"2019-03-27T00:18:25Z"},"accession":"S-EPMC89260","cross_references":{"pubmed":["10223953"],"doi":["10.1128/AAC.43.5.1281"]}}