biostudies-literatureRitz BNIEHS NIH HHSNCI NIH HHS111907https://www.ebi.ac.uk/biostudies/studies/S-EPMC8926017biostudies-literatureUnknown203<h4>Background</h4>Maternal exposure to traffic-related air pollution during pregnancy has been shown to increase the risk of adverse birth outcomes and childhood disorders. High-resolution metabolomics (HRM) has previously been employed to identify metabolic responses to traffic-related air pollution in adults, including pregnant women. Thus far, no studies have examined metabolic effects of air pollution exposure in utero on neonates.<h4>Methods</h4>We retrieved stored neonatal blood spots for 241 children born in California between 1998 and 2007. These children were randomly selected from all California birth rolls to serve as birth-year matched controls for children with retinoblastoma identified from the California cancer registry for a case control study of childhood cancer. We estimEnvironmental researchChild serum metabolome and traffic-related air pollution exposure in pregnancy.PMC8926017R03 CA252788R21 ES018960R21 ES019986Wu JWalker DIHe DUppal KRitz BYan QJones DPHeck JEfalseChild serum metabolome and traffic-related air pollution exposure in pregnancy.<h4>Background</h4>Maternal exposure to traffic-related air pollution during pregnancy has been shown to increase the risk of adverse birth outcomes and childhood disorders. High-resolution metabolomics (HRM) has previously been employed to identify metabolic responses to traffic-related air pollution in adults, including pregnant women. Thus far, no studies have examined metabolic effects of air pollution exposure in utero on neonates.<h4>Methods</h4>We retrieved stored neonatal blood spots for 241 children born in California between 1998 and 2007. These children were randomly selected from all California birth rolls to serve as birth-year matched controls for children with retinoblastoma identified from the California cancer registry for a case control study of childhood cancer. We estim2022-01-01T00:00:00Z2022 Jan2025-04-21T15:22:41.082Z2025-04-21T15:22:41.082ZS-EPMC89260173441946910.1016/j.envres.2021.111907