{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["13"],"submitter":["Li S"],"pubmed_abstract":["<b>Background:</b> The systems pharmacology approach is a target prediction model for traditional Chinese medicine and has been used increasingly in recent years. However, the accuracy of this model to other prediction models is yet to be established. <b>Objective</b> <i>:</i> To compare the systems pharmacology modelwithexperimental gene chip technology by using these models to predict targets of a traditional Chinese medicine formulain the treatment of primary liver cancer. <b>Methods:</b> Systems pharmacology and gene chip target predictions were performed for the traditional Chinese medicine formula <i>ZhenzhuXiaojiTang</i> (ZZXJT). A third square alignment was performed with molecular docking. <b>Results:</b> Identification of systems pharmacology accounted for 17% of targets, whilegene chip-predicted outcomes accounted for 19%.Molecular docking showed that the top ten targets (excludingcommon targets) of the system pharmacology model had better binding free energies than the gene chip model using twocommon targets as a benchmark. For both models, the core drugs predictions were more consistent than the core small molecules predictions. <b>Conclusion:</b>In this study, the identified targets of systems pharmacology weredissimilar to those identified by gene chip technology; whereas the core drug and small molecule predictions were similar."],"journal":["Frontiers in pharmacology"],"pagination":["768862"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8926147"],"repository":["biostudies-literature"],"pubmed_title":["A Comparative Study of Systems Pharmacology and Gene Chip Technology for Predicting Targets of a Traditional Chinese Medicine Formula in Primary Liver Cancer Treatment."],"pmcid":["PMC8926147"],"pubmed_authors":["Li S","Sun Y"],"additional_accession":[]},"is_claimable":false,"name":"A Comparative Study of Systems Pharmacology and Gene Chip Technology for Predicting Targets of a Traditional Chinese Medicine Formula in Primary Liver Cancer Treatment.","description":"<b>Background:</b> The systems pharmacology approach is a target prediction model for traditional Chinese medicine and has been used increasingly in recent years. However, the accuracy of this model to other prediction models is yet to be established. <b>Objective</b> <i>:</i> To compare the systems pharmacology modelwithexperimental gene chip technology by using these models to predict targets of a traditional Chinese medicine formulain the treatment of primary liver cancer. <b>Methods:</b> Systems pharmacology and gene chip target predictions were performed for the traditional Chinese medicine formula <i>ZhenzhuXiaojiTang</i> (ZZXJT). A third square alignment was performed with molecular docking. <b>Results:</b> Identification of systems pharmacology accounted for 17% of targets, whilegene chip-predicted outcomes accounted for 19%.Molecular docking showed that the top ten targets (excludingcommon targets) of the system pharmacology model had better binding free energies than the gene chip model using twocommon targets as a benchmark. For both models, the core drugs predictions were more consistent than the core small molecules predictions. <b>Conclusion:</b>In this study, the identified targets of systems pharmacology weredissimilar to those identified by gene chip technology; whereas the core drug and small molecule predictions were similar.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2024-11-10T06:09:18.129Z","creation":"2024-11-10T06:09:18.129Z"},"accession":"S-EPMC8926147","cross_references":{"pubmed":["35308212"],"doi":["10.3389/fphar.2022.768862"]}}