biostudies-literatureUnknown9Chen B<h4>Background and aims</h4>Hepatocellular carcinoma (HCC) is a common malignant disease with high morbidity and mortality throughout the world. While Borealin is a putative oncogene that is dysregulated in multiple tumors, its exact role in HCC remains less investigated.<h4>Methods</h4>Quantitative reverse transcription polymerase chain reaction (qRT-PCR) and immunohistochemistry (IHC) assays were employed to examine the relative amount of Borealin. Gene set enrichment analysis (GSEA) and other bioinformatic analyses were implemented to probe into the potential functions of Borealin. The biological roles and mechanisms of Borealin in the tumorigenesis and development of HCC were further evaluated using a battery of functional assays in vivo and in vitro.<h4>Results</h4>Borealin was enhancJournal of hepatocellular carcinoma171-188https://www.ebi.ac.uk/biostudies/studies/S-EPMC8926168biostudies-literatureBorealin Promotes Tumor Growth and Metastasis by Activating the Wnt/β-Catenin Signaling Pathway in Hepatocellular Carcinoma.PMC8926168Liu XLiu YLi YDu QGu YLiao XLiu QWang HSun HChen BShen HfalseBorealin Promotes Tumor Growth and Metastasis by Activating the Wnt/β-Catenin Signaling Pathway in Hepatocellular Carcinoma.<h4>Background and aims</h4>Hepatocellular carcinoma (HCC) is a common malignant disease with high morbidity and mortality throughout the world. While Borealin is a putative oncogene that is dysregulated in multiple tumors, its exact role in HCC remains less investigated.<h4>Methods</h4>Quantitative reverse transcription polymerase chain reaction (qRT-PCR) and immunohistochemistry (IHC) assays were employed to examine the relative amount of Borealin. Gene set enrichment analysis (GSEA) and other bioinformatic analyses were implemented to probe into the potential functions of Borealin. The biological roles and mechanisms of Borealin in the tumorigenesis and development of HCC were further evaluated using a battery of functional assays in vivo and in vitro.<h4>Results</h4>Borealin was enhanc2022-01-01T00:00:00Z20222025-05-18T12:33:29.651Z2025-04-04T23:33:34.385ZS-EPMC89261683530860310.2147/JHC.S336452