{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zhang Y"],"funding":["Natural Sciences and Engineering Research Council of Canada"],"pagination":["3233-3243"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8926288"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(11)"],"pubmed_abstract":["Mass cytometry is an emerging powerful bioanalytical technique for high-dimensional single-cell analysis. In this technique, cells are stained with metal-isotope-tagged antibodies and are analyzed by an inductively coupled plasma time-of-flight mass spectrometer. While there are more than 100 stable isotopes available in the <i>m</i>/<i>z</i> 75 to 209 detection range of the instrument, only about 50 parameters can be measured per cell because current reagents are metal-chelating polymers with pendant aminocarboxylate chelators that only bind hard metal ions such as the rare earths and Bi<sup>3+</sup>. Here we describe the synthesis and characterization of a new type of metal-chelating polymer with pendant dipicolylamine chelators suited to binding intermediate to soft metals such as rheni"],"journal":["Chemical science"],"pubmed_title":["Polymeric dipicolylamine based mass tags for mass cytometry."],"pmcid":["PMC8926288"],"funding_grant_id":["CRDPJ 484832 – 15"],"pubmed_authors":["Zhang Y","Majonis D","Liu P","Winnik MA"],"additional_accession":[]},"is_claimable":false,"name":"Polymeric dipicolylamine based mass tags for mass cytometry.","description":"Mass cytometry is an emerging powerful bioanalytical technique for high-dimensional single-cell analysis. In this technique, cells are stained with metal-isotope-tagged antibodies and are analyzed by an inductively coupled plasma time-of-flight mass spectrometer. While there are more than 100 stable isotopes available in the <i>m</i>/<i>z</i> 75 to 209 detection range of the instrument, only about 50 parameters can be measured per cell because current reagents are metal-chelating polymers with pendant aminocarboxylate chelators that only bind hard metal ions such as the rare earths and Bi<sup>3+</sup>. Here we describe the synthesis and characterization of a new type of metal-chelating polymer with pendant dipicolylamine chelators suited to binding intermediate to soft metals such as rheni","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2026-05-09T17:42:05.184Z","creation":"2024-11-10T08:50:04.892Z"},"accession":"S-EPMC8926288","cross_references":{"pubmed":["35414868"],"doi":["10.1039/d2sc00595f"]}}