{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Song L"],"funding":["Social Development Plans of Shaanxi Province"],"pagination":["4914005"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8926463"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["2022"],"pubmed_abstract":["Hypoxia and its induced vasculogenic mimicry (VM) formation, which both closely related with stem-like side population (SP) cells, are the main culprits leading to tumor invasion and metastasis. Sinomenine exhibits excellent anticancer activity in breast cancer, but whether and how it affects hypoxia-triggered VM formation in breast cancer SP cells remains unclear. In this study, breast cancer SP cells were sorted from MDA-MB-231 cells and cultured with sinomenine under hypoxic conditions. Sinomenine obviously repressed the migration and VM formation of breast cancer SP cells. Through downregulating SIAH2 and HIF-1<i>α</i>, sinomenine can inhibit epithelial-mesenchymal transition process of breast cancer SP cells. SIAH2 was identified as a target of miR-340-5p and was downregulated by it, "],"journal":["BioMed research international"],"pubmed_title":["Sinomenine Inhibits Vasculogenic Mimicry and Migration of Breast Cancer Side Population Cells via Regulating miR-340-5p/SIAH2 Axis."],"pmcid":["PMC8926463"],"funding_grant_id":["2019SF-096"],"pubmed_authors":["Song L","Tang L","Zhang H","Hu M","Lu D","Liu C","Liu D","Zhang S","Zhao Y"],"additional_accession":[]},"is_claimable":false,"name":"Sinomenine Inhibits Vasculogenic Mimicry and Migration of Breast Cancer Side Population Cells via Regulating miR-340-5p/SIAH2 Axis.","description":"Hypoxia and its induced vasculogenic mimicry (VM) formation, which both closely related with stem-like side population (SP) cells, are the main culprits leading to tumor invasion and metastasis. Sinomenine exhibits excellent anticancer activity in breast cancer, but whether and how it affects hypoxia-triggered VM formation in breast cancer SP cells remains unclear. In this study, breast cancer SP cells were sorted from MDA-MB-231 cells and cultured with sinomenine under hypoxic conditions. Sinomenine obviously repressed the migration and VM formation of breast cancer SP cells. Through downregulating SIAH2 and HIF-1<i>α</i>, sinomenine can inhibit epithelial-mesenchymal transition process of breast cancer SP cells. SIAH2 was identified as a target of miR-340-5p and was downregulated by it, ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-04T20:23:28.926Z","creation":"2025-04-04T20:23:28.926Z"},"accession":"S-EPMC8926463","cross_references":{"pubmed":["35309179"],"doi":["10.1155/2022/4914005"]}}