{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Zakeri N"],"funding":["Cancer Research UK","National Institute for Health Research (NIHR)","Wellcome Trust"],"pagination":["1372"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8927126"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13(1)"],"pubmed_abstract":["Immunotherapy is now the standard of care for advanced hepatocellular carcinoma (HCC), yet many patients fail to respond. A major unmet goal is the boosting of T-cells with both strong HCC reactivity and the protective advantages of tissue-resident memory T-cells (T<sub>RM</sub>). Here, we show that higher intratumoural frequencies of γδ T-cells, which have potential for HLA-unrestricted tumour reactivity, associate with enhanced HCC patient survival. We demonstrate that γδ T-cells exhibit bona fide tissue-residency in human liver and HCC, with γδT<sub>RM</sub> showing no egress from hepatic vasculature, persistence for >10 years and superior anti-tumour cytokine production. The Vγ9Vδ2 T-cell subset is selectively depleted in HCC but can efficiently target HCC cell lines sensitised to accu"],"journal":["Nature communications"],"pubmed_title":["Characterisation and induction of tissue-resident gamma delta T-cells to target hepatocellular carcinoma."],"pmcid":["PMC8927126"],"funding_grant_id":["214191/Z/18/Z","214191","175479","26603"],"pubmed_authors":["Pinzani M","Zakeri N","Davidson BR","Kucykowicz S","Quaglia A","Amin OE","Gander A","Maini MK","Swadling L","Schmidt NM","Pallett LJ","Diniz MO","Hall A"],"additional_accession":[]},"is_claimable":false,"name":"Characterisation and induction of tissue-resident gamma delta T-cells to target hepatocellular carcinoma.","description":"Immunotherapy is now the standard of care for advanced hepatocellular carcinoma (HCC), yet many patients fail to respond. A major unmet goal is the boosting of T-cells with both strong HCC reactivity and the protective advantages of tissue-resident memory T-cells (T<sub>RM</sub>). Here, we show that higher intratumoural frequencies of γδ T-cells, which have potential for HLA-unrestricted tumour reactivity, associate with enhanced HCC patient survival. We demonstrate that γδ T-cells exhibit bona fide tissue-residency in human liver and HCC, with γδT<sub>RM</sub> showing no egress from hepatic vasculature, persistence for >10 years and superior anti-tumour cytokine production. The Vγ9Vδ2 T-cell subset is selectively depleted in HCC but can efficiently target HCC cell lines sensitised to accu","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-19T22:10:37.133Z","creation":"2025-04-19T22:10:37.133Z"},"accession":"S-EPMC8927126","cross_references":{"pubmed":["35296658"],"doi":["10.1038/s41467-022-29012-1"]}}