biostudies-literatureChueh TYMinistry of Educatione050458https://www.ebi.ac.uk/biostudies/studies/S-EPMC8928248biostudies-literatureUnknown12(3)<h4>Objectives</h4>To review the current evidence on the acute effects of interrupting prolonged periods of sitting with intermittent physical activity (PA) on cognition in healthy populations.<h4>Design</h4>This systematic review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines.<h4>Methods</h4>Studies were included if they investigated the acute effects of taking regular PA breaks from sitting on cognition in healthy populations without any cardiovascular disease, history of brain injury, or psychiatric or neurological disorder. Four electronic databases-PubMed, Scopus, MEDLINE and ProQuest-were searched for eligible studies on 20 September 2020. Study quality was assessed using the Physiotherapy Evidence Database scale.<h4>Results</h4>Seven studiBMJ openAcute effect of breaking up prolonged sitting on cognition: a systematic review.PMC8928248Not applicableHung TMChen YCChueh TYfalseAcute effect of breaking up prolonged sitting on cognition: a systematic review.<h4>Objectives</h4>To review the current evidence on the acute effects of interrupting prolonged periods of sitting with intermittent physical activity (PA) on cognition in healthy populations.<h4>Design</h4>This systematic review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines.<h4>Methods</h4>Studies were included if they investigated the acute effects of taking regular PA breaks from sitting on cognition in healthy populations without any cardiovascular disease, history of brain injury, or psychiatric or neurological disorder. Four electronic databases-PubMed, Scopus, MEDLINE and ProQuest-were searched for eligible studies on 20 September 2020. Study quality was assessed using the Physiotherapy Evidence Database scale.<h4>Results</h4>Seven studi2022-01-01T00:00:00Z2022 Mar2025-04-04T03:20:00.899Z2025-04-04T03:20:00.899ZS-EPMC89282483529248710.1136/bmjopen-2021-050458