{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["9"],"submitter":["Wen N"],"funding":["Clemson University","National Institutes of Health"],"pubmed_abstract":["Wheat is a major source of energy and nutrition worldwide, but it is also a primary cause of frequent diet-induced health issues, specifically celiac disease, for which the only effective therapy so far is strict dietary abstinence from gluten-containing grains. Wheat gluten proteins are grouped into two major categories: high-molecular-weight glutenin subunits (HMWgs), vital for mixing and baking properties, and gliadins plus low-molecular-weight glutenin subunits (LMWgs) that contain the overwhelming majority of celiac-causing epitopes. We put forth a hypothesis that eliminating gliadins and LMWgs while retaining HMWgs might allow the development of reduced-immunogenicity wheat genotypes relevant to most gluten-sensitive individuals. This hypothesis stems from the knowledge that the mole"],"journal":["Frontiers in nutrition"],"pagination":["847635"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8928260"],"repository":["biostudies-literature"],"pubmed_title":["Targeting Induced Local Lesions in the Wheat <i>DEMETER</i> and <i>DRE2</i> Genes, Responsible for Transcriptional Derepression of Wheat Gluten Proteins in the Developing Endosperm."],"pmcid":["PMC8928260"],"pubmed_authors":["Rustgi S","Alam T","Reinbothe S","Reinbothe C","Wen N","Osorio CE","Brew-Appiah RAT","Kashyap S","Moehs CP","Mejias JH","von Wettstein D"],"additional_accession":[]},"is_claimable":false,"name":"Targeting Induced Local Lesions in the Wheat <i>DEMETER</i> and <i>DRE2</i> Genes, Responsible for Transcriptional Derepression of Wheat Gluten Proteins in the Developing Endosperm.","description":"Wheat is a major source of energy and nutrition worldwide, but it is also a primary cause of frequent diet-induced health issues, specifically celiac disease, for which the only effective therapy so far is strict dietary abstinence from gluten-containing grains. Wheat gluten proteins are grouped into two major categories: high-molecular-weight glutenin subunits (HMWgs), vital for mixing and baking properties, and gliadins plus low-molecular-weight glutenin subunits (LMWgs) that contain the overwhelming majority of celiac-causing epitopes. We put forth a hypothesis that eliminating gliadins and LMWgs while retaining HMWgs might allow the development of reduced-immunogenicity wheat genotypes relevant to most gluten-sensitive individuals. This hypothesis stems from the knowledge that the mole","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2026-04-08T18:33:08.227Z","creation":"2024-10-16T15:04:36.351Z"},"accession":"S-EPMC8928260","cross_references":{"pubmed":["35308262"],"doi":["10.3389/fnut.2022.847635"]}}