{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(1)"],"submitter":["Puechal X"],"pubmed_abstract":["<h4>Objective</h4>To investigate whether antineutrophil cytoplasm antibody (ANCA)-negative and myeloperoxidase (MPO)-ANCA-positive granulomatosis with polyangiitis (GPA) differ from proteinase-3 (PR3)-ANCA-positive GPA.<h4>Methods</h4>Diagnostic characteristics and outcomes of newly diagnosed French Vasculitis Study Group Registry patients with ANCA-negative, MPO-ANCA-positive or PR3-ANCA-positive GPA satisfying American College of Rheumatology criteria and/or Chapel Hill Conference Consensus Nomenclature were compared.<h4>Results</h4>Among 727 GPA, 62 (8.5%) were ANCA-negative, 119 (16.4%) MPO-ANCA-positive and 546 (75.1%) PR3-ANCA-positive. ANCA-negative patients had significantly (p<0.05) more limited disease (17.7% vs 5.8%) and less kidney involvement (35.5% vs 58.9%) than those PR3-AN"],"journal":["RMD open"],"pagination":["e002160"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8928389"],"repository":["biostudies-literature"],"pubmed_title":["Comparative study of granulomatosis with polyangiitis subsets according to ANCA status: data from the French Vasculitis Study Group Registry."],"pmcid":["PMC8928389"],"pubmed_authors":["de Moreuil C","Blanchard-Delaunay C","Puechal X","Hachulla E","Terrier B","Hamidou M","Ruivard M","Quemeneur T","Lifermann F","Cohen P","Le Quellec A","Khouatra C","Mouthon L","Pagnoux C","Guillevin L","Jourde-Chiche N","Bonnotte B","Maurier F","Viallard JF","French Vasculitis Study Group","Iudici M","Godmer P","Le Gallou T","Aumaitre O","Karras A","Aouba A"],"additional_accession":[]},"is_claimable":false,"name":"Comparative study of granulomatosis with polyangiitis subsets according to ANCA status: data from the French Vasculitis Study Group Registry.","description":"<h4>Objective</h4>To investigate whether antineutrophil cytoplasm antibody (ANCA)-negative and myeloperoxidase (MPO)-ANCA-positive granulomatosis with polyangiitis (GPA) differ from proteinase-3 (PR3)-ANCA-positive GPA.<h4>Methods</h4>Diagnostic characteristics and outcomes of newly diagnosed French Vasculitis Study Group Registry patients with ANCA-negative, MPO-ANCA-positive or PR3-ANCA-positive GPA satisfying American College of Rheumatology criteria and/or Chapel Hill Conference Consensus Nomenclature were compared.<h4>Results</h4>Among 727 GPA, 62 (8.5%) were ANCA-negative, 119 (16.4%) MPO-ANCA-positive and 546 (75.1%) PR3-ANCA-positive. ANCA-negative patients had significantly (p<0.05) more limited disease (17.7% vs 5.8%) and less kidney involvement (35.5% vs 58.9%) than those PR3-AN","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2026-06-07T03:22:26.133Z","creation":"2025-04-04T23:02:42.772Z"},"accession":"S-EPMC8928389","cross_references":{"pubmed":["35296533"],"doi":["10.1136/rmdopen-2021-002160"]}}