biostudies-literatureUnknown8(1)Puechal X<h4>Objective</h4>To investigate whether antineutrophil cytoplasm antibody (ANCA)-negative and myeloperoxidase (MPO)-ANCA-positive granulomatosis with polyangiitis (GPA) differ from proteinase-3 (PR3)-ANCA-positive GPA.<h4>Methods</h4>Diagnostic characteristics and outcomes of newly diagnosed French Vasculitis Study Group Registry patients with ANCA-negative, MPO-ANCA-positive or PR3-ANCA-positive GPA satisfying American College of Rheumatology criteria and/or Chapel Hill Conference Consensus Nomenclature were compared.<h4>Results</h4>Among 727 GPA, 62 (8.5%) were ANCA-negative, 119 (16.4%) MPO-ANCA-positive and 546 (75.1%) PR3-ANCA-positive. ANCA-negative patients had significantly (p<0.05) more limited disease (17.7% vs 5.8%) and less kidney involvement (35.5% vs 58.9%) than those PR3-ANRMD opene002160https://www.ebi.ac.uk/biostudies/studies/S-EPMC8928389biostudies-literatureComparative study of granulomatosis with polyangiitis subsets according to ANCA status: data from the French Vasculitis Study Group Registry.PMC8928389de Moreuil CBlanchard-Delaunay CPuechal XHachulla ETerrier BHamidou MRuivard MQuemeneur TLifermann FCohen PLe Quellec AKhouatra CMouthon LPagnoux CGuillevin LJourde-Chiche NBonnotte BMaurier FViallard JFFrench Vasculitis Study GroupIudici MGodmer PLe Gallou TAumaitre OKarras AAouba AfalseComparative study of granulomatosis with polyangiitis subsets according to ANCA status: data from the French Vasculitis Study Group Registry.<h4>Objective</h4>To investigate whether antineutrophil cytoplasm antibody (ANCA)-negative and myeloperoxidase (MPO)-ANCA-positive granulomatosis with polyangiitis (GPA) differ from proteinase-3 (PR3)-ANCA-positive GPA.<h4>Methods</h4>Diagnostic characteristics and outcomes of newly diagnosed French Vasculitis Study Group Registry patients with ANCA-negative, MPO-ANCA-positive or PR3-ANCA-positive GPA satisfying American College of Rheumatology criteria and/or Chapel Hill Conference Consensus Nomenclature were compared.<h4>Results</h4>Among 727 GPA, 62 (8.5%) were ANCA-negative, 119 (16.4%) MPO-ANCA-positive and 546 (75.1%) PR3-ANCA-positive. ANCA-negative patients had significantly (p<0.05) more limited disease (17.7% vs 5.8%) and less kidney involvement (35.5% vs 58.9%) than those PR3-AN2022-01-01T00:00:00Z2022 Mar2026-06-07T03:22:26.133Z2025-04-04T23:02:42.772ZS-EPMC89283893529653310.1136/rmdopen-2021-002160