{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12"],"submitter":["Chen Y"],"funding":["Natural Science Foundation of Zhejiang Province","National Natural Science Foundation of China"],"pubmed_abstract":["Tanshinones found in <i>Salvia</i> species are the main active compounds for the treatment of cardiovascular and cerebrovascular diseases, but their contents are hugely different in different species. For example, tanshinone IIA content in <i>Salvia castanea</i> Diels f. <i>tomentosa</i> Stib. is about 49 times higher than that in <i>Salvia miltiorrhiza</i> Bunge. The molecular mechanism responsible for this phenomenon remains largely unknown. To address this, we performed comparative transcriptomic and proteomic analyses of <i>S. miltiorrhiza</i> and <i>S. castanea</i>. A total of 296 genes in <i>S. castanea</i> and 125 genes in <i>S. miltiorrhiza</i> were highly expressed at both the transcriptional and proteome levels, including hormone signal regulation, fungus response genes, transcri"],"journal":["Frontiers in plant science"],"pagination":["820582"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8928407"],"repository":["biostudies-literature"],"pubmed_title":["Integrated Transcriptomics and Proteomics to Reveal Regulation Mechanism and Evolution of <i>SmWRKY61</i> on Tanshinone Biosynthesis in <i>Salvia miltiorrhiza</i> and <i>Salvia castanea</i>."],"pmcid":["PMC8928407"],"pubmed_authors":["Dennis M","Yang J","Liang Z","Du Z","Huang L","Yang D","Wei Y","Cheng Y","Guo J","Qi Z","Huang Y","Zhang X","Chen Y","Wang Y","Wang Z"],"additional_accession":[]},"is_claimable":false,"name":"Integrated Transcriptomics and Proteomics to Reveal Regulation Mechanism and Evolution of <i>SmWRKY61</i> on Tanshinone Biosynthesis in <i>Salvia miltiorrhiza</i> and <i>Salvia castanea</i>.","description":"Tanshinones found in <i>Salvia</i> species are the main active compounds for the treatment of cardiovascular and cerebrovascular diseases, but their contents are hugely different in different species. For example, tanshinone IIA content in <i>Salvia castanea</i> Diels f. <i>tomentosa</i> Stib. is about 49 times higher than that in <i>Salvia miltiorrhiza</i> Bunge. The molecular mechanism responsible for this phenomenon remains largely unknown. To address this, we performed comparative transcriptomic and proteomic analyses of <i>S. miltiorrhiza</i> and <i>S. castanea</i>. A total of 296 genes in <i>S. castanea</i> and 125 genes in <i>S. miltiorrhiza</i> were highly expressed at both the transcriptional and proteome levels, including hormone signal regulation, fungus response genes, transcri","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021","modification":"2026-05-31T04:01:28.325Z","creation":"2025-02-19T01:53:31.909Z"},"accession":"S-EPMC8928407","cross_references":{"pubmed":["35309951"],"doi":["10.3389/fpls.2021.820582"]}}