biostudies-literatureUnknown12Chen YNatural Science Foundation of Zhejiang ProvinceNational Natural Science Foundation of ChinaTanshinones found in <i>Salvia</i> species are the main active compounds for the treatment of cardiovascular and cerebrovascular diseases, but their contents are hugely different in different species. For example, tanshinone IIA content in <i>Salvia castanea</i> Diels f. <i>tomentosa</i> Stib. is about 49 times higher than that in <i>Salvia miltiorrhiza</i> Bunge. The molecular mechanism responsible for this phenomenon remains largely unknown. To address this, we performed comparative transcriptomic and proteomic analyses of <i>S. miltiorrhiza</i> and <i>S. castanea</i>. A total of 296 genes in <i>S. castanea</i> and 125 genes in <i>S. miltiorrhiza</i> were highly expressed at both the transcriptional and proteome levels, including hormone signal regulation, fungus response genes, transcriFrontiers in plant science820582https://www.ebi.ac.uk/biostudies/studies/S-EPMC8928407biostudies-literatureIntegrated Transcriptomics and Proteomics to Reveal Regulation Mechanism and Evolution of <i>SmWRKY61</i> on Tanshinone Biosynthesis in <i>Salvia miltiorrhiza</i> and <i>Salvia castanea</i>.PMC8928407Dennis MYang JLiang ZDu ZHuang LYang DWei YCheng YGuo JQi ZHuang YZhang XChen YWang YWang ZfalseIntegrated Transcriptomics and Proteomics to Reveal Regulation Mechanism and Evolution of <i>SmWRKY61</i> on Tanshinone Biosynthesis in <i>Salvia miltiorrhiza</i> and <i>Salvia castanea</i>.Tanshinones found in <i>Salvia</i> species are the main active compounds for the treatment of cardiovascular and cerebrovascular diseases, but their contents are hugely different in different species. For example, tanshinone IIA content in <i>Salvia castanea</i> Diels f. <i>tomentosa</i> Stib. is about 49 times higher than that in <i>Salvia miltiorrhiza</i> Bunge. The molecular mechanism responsible for this phenomenon remains largely unknown. To address this, we performed comparative transcriptomic and proteomic analyses of <i>S. miltiorrhiza</i> and <i>S. castanea</i>. A total of 296 genes in <i>S. castanea</i> and 125 genes in <i>S. miltiorrhiza</i> were highly expressed at both the transcriptional and proteome levels, including hormone signal regulation, fungus response genes, transcri2021-01-01T00:00:00Z20212026-05-31T04:01:28.325Z2025-02-19T01:53:31.909ZS-EPMC89284073530995110.3389/fpls.2021.820582