biostudies-literatureRodriguez JMMUniversität ZÜrich269-283https://www.ebi.ac.uk/biostudies/studies/S-EPMC8928422biostudies-literatureUnknown59(2)The sequence of pathological events in feline hypertrophic cardiomyopathy (fHCM) is still largely unknown, although we know that fHCM is characterized by interstitial remodeling in a macrophage-driven pro-inflammatory environment and that myocardial ischemia might contribute to its progression. This study aimed to gain further insights into the structural changes associated with interstitial remodeling in fHCM with special focus on the myocardial microvasculature and the phenotype of the interstitial cells. Twenty-eight hearts (16 hearts with fHCM and 12 without cardiac disease) were evaluated in the current study, with immunohistochemistry, RNA-in situ hybridization, and transmission electron microscopy. Morphometrical evaluations revealed a statistically significant lower microvascular dVeterinary pathologyFeline hypertrophic cardiomyopathy: reduced microvascular density and involvement of CD34+ interstitial cells.PMC8928422Center for Applied Biotechnology and Molecular MedFonfara SRodriguez JMMKipar AHetzel UfalseFeline hypertrophic cardiomyopathy: reduced microvascular density and involvement of CD34+ interstitial cells.The sequence of pathological events in feline hypertrophic cardiomyopathy (fHCM) is still largely unknown, although we know that fHCM is characterized by interstitial remodeling in a macrophage-driven pro-inflammatory environment and that myocardial ischemia might contribute to its progression. This study aimed to gain further insights into the structural changes associated with interstitial remodeling in fHCM with special focus on the myocardial microvasculature and the phenotype of the interstitial cells. Twenty-eight hearts (16 hearts with fHCM and 12 without cardiac disease) were evaluated in the current study, with immunohistochemistry, RNA-in situ hybridization, and transmission electron microscopy. Morphometrical evaluations revealed a statistically significant lower microvascular d2022-01-01T00:00:00Z2022 Mar2026-06-18T05:04:30.054Z2025-04-06T10:58:15.452ZS-EPMC89284223495506710.1177/03009858211062631