{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Wei M"],"funding":["National Natural Science Foundation of China","Southwest Minzu University"],"pagination":["8980-8987"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8928518"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["7(10)"],"pubmed_abstract":["A microreactor (MR) with a vaporization microchamber and a sinusoidal wave microchannel was fabricated to synthesize 2-cyanopyrazine (CP) directly with an aqueous 2-methylpyrazine (MP) solution. A continuous-flow process with high space-time yield was achieved under the premise of strong exothermality of this ammoxidation reaction. The vanadium metal oxide catalysts with four different supports (α-Al<sub>2</sub>O<sub>3</sub>, γ-Al<sub>2</sub>O<sub>3</sub>, ZSM-5(50), ZSM-5(80)) were evaluated by simply stacking in the wave microchannel from 350 to 540 °C. The process parameters (temperature, reactant ratio, and size of catalysts) were optimized with the selected CrVPO/γ-Al<sub>2</sub>O<sub>3</sub> catalyst, and an optimal ammoxidation process with MP conversion (<i>X</i> <sub>MP</sub>) of 71.5% and CP selectivity (<i>S</i> <sub>CP</sub>) of 93.7% was obtained by a volume space velocity (GHSV) of 13 081 h<sup>-1</sup> at 480 °C. Correspondingly, the space-time yield of CP (STY<sub>CP</sub>) was 1724-77 082 g<sub>CP</sub>kg<sub>cat</sub> <sup>-1</sup>h<sup>-1</sup>, which was the highest value ever reported for this reaction. Meanwhile, the ammoxidation reaction showed a great continuous-synthesis stability of 50-h running in the microreactor with the CP yield (<i>Y</i> <sub>CP</sub>) remaining 56%-68%."],"journal":["ACS omega"],"pubmed_title":["Continuous-Flow Ammoxidation of 2-Methylpyrazine to 2-Cyanopyrazine with High Space-Time Yield in a Microreactor."],"pmcid":["PMC8928518"],"funding_grant_id":["21406183","CX2020SZ15"],"pubmed_authors":["Wei M","Ma H","Ma Z","Chen X","Lu Q","Ruan D"],"additional_accession":[]},"is_claimable":false,"name":"Continuous-Flow Ammoxidation of 2-Methylpyrazine to 2-Cyanopyrazine with High Space-Time Yield in a Microreactor.","description":"A microreactor (MR) with a vaporization microchamber and a sinusoidal wave microchannel was fabricated to synthesize 2-cyanopyrazine (CP) directly with an aqueous 2-methylpyrazine (MP) solution. A continuous-flow process with high space-time yield was achieved under the premise of strong exothermality of this ammoxidation reaction. The vanadium metal oxide catalysts with four different supports (α-Al<sub>2</sub>O<sub>3</sub>, γ-Al<sub>2</sub>O<sub>3</sub>, ZSM-5(50), ZSM-5(80)) were evaluated by simply stacking in the wave microchannel from 350 to 540 °C. The process parameters (temperature, reactant ratio, and size of catalysts) were optimized with the selected CrVPO/γ-Al<sub>2</sub>O<sub>3</sub> catalyst, and an optimal ammoxidation process with MP conversion (<i>X</i> <sub>MP</sub>) of 71.5% and CP selectivity (<i>S</i> <sub>CP</sub>) of 93.7% was obtained by a volume space velocity (GHSV) of 13 081 h<sup>-1</sup> at 480 °C. Correspondingly, the space-time yield of CP (STY<sub>CP</sub>) was 1724-77 082 g<sub>CP</sub>kg<sub>cat</sub> <sup>-1</sup>h<sup>-1</sup>, which was the highest value ever reported for this reaction. Meanwhile, the ammoxidation reaction showed a great continuous-synthesis stability of 50-h running in the microreactor with the CP yield (<i>Y</i> <sub>CP</sub>) remaining 56%-68%.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-18T14:14:37.17Z","creation":"2025-04-04T20:23:19.203Z"},"accession":"S-EPMC8928518","cross_references":{"pubmed":["35309436"],"doi":["10.1021/acsomega.2c00039"]}}