{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Macchia A"],"funding":["Ministero dell?Istruzione, dell?Universit? e della Ricerca","Austrian Science Fund FWF"],"pagination":["8808-8818"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8928520"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["7(10)"],"pubmed_abstract":["1,4-Conjugate addition of ((chloromethyl)sulfonyl)benzenes to arylideneisoxazol-5-ones, followed by one-pot, N-selective trapping in the presence of electrophiles, was investigated. This strategy led to the synthesis of new, stable N-protected isoxazol-5-ones in good yields and high diastereolectivity. The study of the reactivity of obtained products in the presence of the Mo(CO)<sub>6</sub>/H<sub>2</sub>O system allowed the development of a cascade reaction leading to novel methyl ketones in high yields and unchanged dr bearing an uncommon chloromethinearylsulfonyl end group."],"journal":["ACS omega"],"pubmed_title":["Access to β-Alkylated γ-Functionalized Ketones via Conjugate Additions to Arylideneisoxazol-5-ones and Mo(CO)<sub>6</sub>-Mediated Reductive Cascade Reactions."],"pmcid":["PMC8928520"],"funding_grant_id":["J-4592"],"pubmed_authors":["Monaco G","Eitzinger A","Summa FF","Macchia A","Di Mola A","Ofial AR","Massa A"],"additional_accession":[]},"is_claimable":false,"name":"Access to β-Alkylated γ-Functionalized Ketones via Conjugate Additions to Arylideneisoxazol-5-ones and Mo(CO)<sub>6</sub>-Mediated Reductive Cascade Reactions.","description":"1,4-Conjugate addition of ((chloromethyl)sulfonyl)benzenes to arylideneisoxazol-5-ones, followed by one-pot, N-selective trapping in the presence of electrophiles, was investigated. This strategy led to the synthesis of new, stable N-protected isoxazol-5-ones in good yields and high diastereolectivity. The study of the reactivity of obtained products in the presence of the Mo(CO)<sub>6</sub>/H<sub>2</sub>O system allowed the development of a cascade reaction leading to novel methyl ketones in high yields and unchanged dr bearing an uncommon chloromethinearylsulfonyl end group.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-04T14:49:37.035Z","creation":"2025-04-04T14:49:37.035Z"},"accession":"S-EPMC8928520","cross_references":{"pubmed":["35309475"],"doi":["10.1021/acsomega.1c07081"]}}