{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Nandy P"],"funding":["Jadavpur University","University Grants Commission","University of Engineering &amp; Management, Kolkata","Department of Science and Technology, Ministry of Science and Technology, India"],"pagination":["8268-8280"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8928527"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["7(10)"],"pubmed_abstract":["Formation of nitro radical anion (-NO<sub>2</sub> <sup>•-</sup>) and other reduction products of 5-nitroimidazoles, although important for antimicrobial activity, makes the drugs neurotoxic. Hence, an appropriate generation and their role in the free radical pathway needs proper realization. This was attempted by studying the action of tinidazole and its Cu<sup>II</sup> complexes on model targets (nucleic acid bases and calf thymus DNA). Results obtained were correlated with studies on biological species where prevention of biofilm formation on <i>Staphylococcus aureus</i> and <i>Pseudomonas aeruginosa</i> was followed. Tinidazole and its Cu<sup>II</sup> complexes subjected to electrochemical reduction in aqueous solution, under de-aerated conditions, interact with model nucleic acid bases"],"journal":["ACS omega"],"pubmed_title":["In Situ Reactivity of Electrochemically Generated Nitro Radical Anion on Tinidazole and Its Monomeric and Dimeric Cu<sup>II</sup> Complexes on Model Biological Targets with Relative Manifestation of Preventing Bacterial Biofilm Formation."],"pmcid":["PMC8928527"],"funding_grant_id":["R-11/438/19"],"pubmed_authors":["Das S","Nandy P","Nag M","Santra RC","Lahiri D"],"additional_accession":[]},"is_claimable":false,"name":"In Situ Reactivity of Electrochemically Generated Nitro Radical Anion on Tinidazole and Its Monomeric and Dimeric Cu<sup>II</sup> Complexes on Model Biological Targets with Relative Manifestation of Preventing Bacterial Biofilm Formation.","description":"Formation of nitro radical anion (-NO<sub>2</sub> <sup>•-</sup>) and other reduction products of 5-nitroimidazoles, although important for antimicrobial activity, makes the drugs neurotoxic. Hence, an appropriate generation and their role in the free radical pathway needs proper realization. This was attempted by studying the action of tinidazole and its Cu<sup>II</sup> complexes on model targets (nucleic acid bases and calf thymus DNA). Results obtained were correlated with studies on biological species where prevention of biofilm formation on <i>Staphylococcus aureus</i> and <i>Pseudomonas aeruginosa</i> was followed. Tinidazole and its Cu<sup>II</sup> complexes subjected to electrochemical reduction in aqueous solution, under de-aerated conditions, interact with model nucleic acid bases","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-25T22:59:11.546Z","creation":"2025-04-06T09:11:46.988Z"},"accession":"S-EPMC8928527","cross_references":{"pubmed":["35309450"],"doi":["10.1021/acsomega.1c04822"]}}