{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["7(2)"],"submitter":["Tscha MK"],"funding":["Conselho Nacional de Desenvolvimento Científico e Tecnológico","Fundação Oswaldo Cruz"],"pubmed_abstract":["Genomic and epidemiological surveillance are paramount for the discovery of new viruses with the potential to cross species barriers. Here, we present a new member of the genus <i>Alphavirus</i> found in <i>Trichoprosopon</i> and <i>Wyeomia</i> mosquitoes, tentatively named Pirahy virus (PIRAV). PIRAV was isolated from mosquito pools collected in a rural area of Piraí do Sul, South Brazil. <i>In vitro</i> assays revealed that PIRAV replicates and causes cytopathic effects in vertebrate cell lines such as Vero E6, SH-SY5Y, BHK-21 and UMNSAH/DF-1. Genomic signature analysis supports these results showing a dinucleotide and codon usage balance compatible with several hosts. Phylogenetic analyses placed PIRAV basal to the Venezuelan equine encephalitis complex. Genome analyses, electron micros"],"journal":["Virus evolution"],"pagination":["veab105"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8928568"],"repository":["biostudies-literature"],"pubmed_title":["Pirahy virus: Identification of a new and potential emerging arbovirus in South Brazil."],"pmcid":["PMC8928568"],"pubmed_authors":["da Silva AM","Soares Medeiros LC","Mattoso Coelho G","Tscha MK","Suzukawa AA","Duarte Dos Santos CN","Ferreira AC","Zanluca C","Rodrigues-Luiz GF","Mansur D","Cataneo AHD"],"additional_accession":[]},"is_claimable":false,"name":"Pirahy virus: Identification of a new and potential emerging arbovirus in South Brazil.","description":"Genomic and epidemiological surveillance are paramount for the discovery of new viruses with the potential to cross species barriers. Here, we present a new member of the genus <i>Alphavirus</i> found in <i>Trichoprosopon</i> and <i>Wyeomia</i> mosquitoes, tentatively named Pirahy virus (PIRAV). PIRAV was isolated from mosquito pools collected in a rural area of Piraí do Sul, South Brazil. <i>In vitro</i> assays revealed that PIRAV replicates and causes cytopathic effects in vertebrate cell lines such as Vero E6, SH-SY5Y, BHK-21 and UMNSAH/DF-1. Genomic signature analysis supports these results showing a dinucleotide and codon usage balance compatible with several hosts. Phylogenetic analyses placed PIRAV basal to the Venezuelan equine encephalitis complex. Genome analyses, electron micros","dates":{"release":"2021-01-01T00:00:00Z","publication":"2021 Sep","modification":"2026-04-08T17:24:40.774Z","creation":"2024-11-13T00:59:00.764Z"},"accession":"S-EPMC8928568","cross_references":{"pubmed":["35310294"],"doi":["10.1093/ve/veab105"]}}