{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Ishiya K"],"funding":["Japan Society for the Promotion of Science"],"pagination":["498-504"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8928963"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["44(2)"],"pubmed_abstract":["Homopolymeric tracts (HPTs) can lead to phase variation and DNA replication slippage, driving adaptation to environmental changes and evolution of genes and genomes. However, there is limited information on HPTs in <i>Escherichia</i>; therefore, we conducted a comprehensive cross-strain search for HPTs in <i>Escherichia</i> genomes. We determined the HPT genomic distribution and identified a pattern of high-frequency HPT localization in pathogenic <i>Escherichia</i> lineages. Notably, HPTs localized near transcriptional regulatory genes. Additionally, excessive repeats accumulated in toxin-coding genes. Moreover, the genomic localization of some HPTs might be derived from exogenous DNA, such as that of bacteriophages. Altogether, our findings may prove useful for understanding the role of "],"journal":["Current issues in molecular biology"],"pubmed_title":["Comparative Genome Analysis Reveals Accumulation of Single-Nucleotide Repeats in Pathogenic <i>Escherichia</i> Lineages."],"pmcid":["PMC8928963"],"funding_grant_id":["19K16246 20H05822 21H04358"],"pubmed_authors":["Nakashima N","Ishiya K"],"additional_accession":[]},"is_claimable":false,"name":"Comparative Genome Analysis Reveals Accumulation of Single-Nucleotide Repeats in Pathogenic <i>Escherichia</i> Lineages.","description":"Homopolymeric tracts (HPTs) can lead to phase variation and DNA replication slippage, driving adaptation to environmental changes and evolution of genes and genomes. However, there is limited information on HPTs in <i>Escherichia</i>; therefore, we conducted a comprehensive cross-strain search for HPTs in <i>Escherichia</i> genomes. We determined the HPT genomic distribution and identified a pattern of high-frequency HPT localization in pathogenic <i>Escherichia</i> lineages. Notably, HPTs localized near transcriptional regulatory genes. Additionally, excessive repeats accumulated in toxin-coding genes. Moreover, the genomic localization of some HPTs might be derived from exogenous DNA, such as that of bacteriophages. Altogether, our findings may prove useful for understanding the role of ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jan","modification":"2025-04-25T18:02:09.148Z","creation":"2025-04-25T18:02:09.148Z"},"accession":"S-EPMC8928963","cross_references":{"pubmed":["35723320"],"doi":["10.3390/cimb44020034"]}}