{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["McClean AR"],"funding":["CIHR"],"pagination":["E183-E189"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8929426"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10(1)"],"pubmed_abstract":["<h4>Background</h4>Socioeconomic status has been associated with higher viral loads and lower CD4 cell counts among people living with HIV. The objective of this study was to evaluate the relation between neighbourhood-level material deprivation and immunologic and virologic response to combination antiretroviral therapy (ART) among people living with HIV in Canada.<h4>Methods</h4>The Canadian Observational Cohort (CANOC) is a longitudinal cohort of people living with HIV, containing data from 2000-2016 from 5 Canadian provinces. We defined response to combination ART as positive if the CD4 cell count increased by 50 cells/mm<sup>3</sup> (0.05 cells × 10<sup>9</sup>/L) or more (CD4+) and viral load decreased to 50 copies/mL or less (VL+) within 6 months of treatment initiation. We further "],"journal":["CMAJ open"],"pubmed_title":["Neighbourhood-level material deprivation and response to combination antiretroviral therapy in the Canadian Observational Cohort (CANOC): a longitudinal cohort study."],"pmcid":["PMC8929426"],"funding_grant_id":["CTN #242","CIHR #134047","CIHR#02684","CIHR #136882","CIHR #143342"],"pubmed_authors":["Bacani N","Loutfy M","CANOC Collaboration","Walmsley SL","Kooij KW","Machouf N","Sereda P","Ye M","Hui C","Kelly D","Burchell AN","Montaner JSG","McLinden T","McClean AR","Trigg J","Hogg RS"],"additional_accession":[]},"is_claimable":false,"name":"Neighbourhood-level material deprivation and response to combination antiretroviral therapy in the Canadian Observational Cohort (CANOC): a longitudinal cohort study.","description":"<h4>Background</h4>Socioeconomic status has been associated with higher viral loads and lower CD4 cell counts among people living with HIV. The objective of this study was to evaluate the relation between neighbourhood-level material deprivation and immunologic and virologic response to combination antiretroviral therapy (ART) among people living with HIV in Canada.<h4>Methods</h4>The Canadian Observational Cohort (CANOC) is a longitudinal cohort of people living with HIV, containing data from 2000-2016 from 5 Canadian provinces. We defined response to combination ART as positive if the CD4 cell count increased by 50 cells/mm<sup>3</sup> (0.05 cells × 10<sup>9</sup>/L) or more (CD4+) and viral load decreased to 50 copies/mL or less (VL+) within 6 months of treatment initiation. We further ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jan-Mar","modification":"2025-04-04T12:43:49.844Z","creation":"2025-04-04T12:43:49.844Z"},"accession":"S-EPMC8929426","cross_references":{"pubmed":["35292476"],"doi":["10.9778/cmajo.20200249"]}}