biostudies-literatureSun CNational Natural Science Foundation of ChinaBeijing Natural Science FoundationSpecial fund for youth clinical research of Peking University First Hospitale0264891https://www.ebi.ac.uk/biostudies/studies/S-EPMC8929647biostudies-literatureUnknown17(3)Both hydrogen sulfide (H2S) and sulfur dioxide (SO2) are produced endogenously from the mammalian metabolic pathway of sulfur-containing amino acids and play important roles in several vascular diseases. However, their interaction during the control of vascular function has not been fully clear. Here, we investigated the potential role of H2S in SO2 production and vascular regulation in vivo and in vitro. Wistar rats were divided into the vehicle, SO2, DL-propargylglycine (PPG) + SO2, β-cyano-L-alanine (BCA) + SO2 and sodium hydrosulfide (NaHS) + SO2 groups. SO2 donor was administered with or without pre-administration of PPG, BCA or NaHS for 30 min after blood pressure was stabilized for 1 h, and then, the change in blood pressure was detected by catheterization via the common carotid artPloS oneRole of hydrogen sulfide in sulfur dioxide production and vascular regulation.PMC892964771910122019CR208177042281770278819704248207044581921001Jin HDu SHuang YZhang YSun CZhang HLv BYu WDu JSun YfalseRole of hydrogen sulfide in sulfur dioxide production and vascular regulation.Both hydrogen sulfide (H2S) and sulfur dioxide (SO2) are produced endogenously from the mammalian metabolic pathway of sulfur-containing amino acids and play important roles in several vascular diseases. However, their interaction during the control of vascular function has not been fully clear. Here, we investigated the potential role of H2S in SO2 production and vascular regulation in vivo and in vitro. Wistar rats were divided into the vehicle, SO2, DL-propargylglycine (PPG) + SO2, β-cyano-L-alanine (BCA) + SO2 and sodium hydrosulfide (NaHS) + SO2 groups. SO2 donor was administered with or without pre-administration of PPG, BCA or NaHS for 30 min after blood pressure was stabilized for 1 h, and then, the change in blood pressure was detected by catheterization via the common carotid art2022-01-01T00:00:00Z20222025-04-04T13:48:59.472Z2025-04-04T13:48:59.472ZS-EPMC89296473529848510.1371/journal.pone.0264891