biostudies-literatureSmelson DAHSRD VAQuality Enhancement Research Initiativee0265396https://www.ebi.ac.uk/biostudies/studies/S-EPMC8929696biostudies-literatureUnknown17(3)<h4>Background</h4>Healthcare systems face difficulty implementing evidence-based practices, particularly multicomponent interventions. Additional challenges occur in settings serving vulnerable populations such as homeless Veterans, given the population's acuity, multiple service needs, and organizational barriers. Implementation Facilitation (IF) is a strategy to support the uptake of evidence-based practices. This study's aim was to simultaneously examine IF on the uptake of Maintaining Independence and Sobriety Through Systems Integration, Outreach and Networking-Veterans Edition (MISSION-Vet), an evidence-based multicomponent treatment engagement intervention for homeless Veterans with co-occurring mental health and substance abuse, and clinical outcomes among Veterans receiving MISSIPloS oneTesting implementation facilitation for uptake of an evidence-based psychosocial intervention in VA homeless programs: A hybrid type III trial.PMC8929696IK2 HX002089QUE 15-284Smith JLGabrielian SByrne TSmelson DABruzios KEMcCullough MBYakovchenko VfalseTesting implementation facilitation for uptake of an evidence-based psychosocial intervention in VA homeless programs: A hybrid type III trial.<h4>Background</h4>Healthcare systems face difficulty implementing evidence-based practices, particularly multicomponent interventions. Additional challenges occur in settings serving vulnerable populations such as homeless Veterans, given the population's acuity, multiple service needs, and organizational barriers. Implementation Facilitation (IF) is a strategy to support the uptake of evidence-based practices. This study's aim was to simultaneously examine IF on the uptake of Maintaining Independence and Sobriety Through Systems Integration, Outreach and Networking-Veterans Edition (MISSION-Vet), an evidence-based multicomponent treatment engagement intervention for homeless Veterans with co-occurring mental health and substance abuse, and clinical outcomes among Veterans receiving MISSI2022-01-01T00:00:00Z20222026-04-08T17:21:11.391Z2025-02-19T05:05:29.903ZS-EPMC89296963529851410.1371/journal.pone.0265396