{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Boknas N"],"funding":["Hjärt-Lungfonden","Region Östergötland"],"pagination":["97-104"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8930184"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["213"],"pubmed_abstract":["In this single-center cohort study, we applied a panel of laboratory markers to characterize hemostatic function in 217 consecutive patients that underwent testing for COVID-19 as they were admitted to Linköping University Hospital between April and June 2020. In the 96 patients that tested positive for SARS-CoV-2 (COVID-19+), the cumulative incidences of death and venous thromboembolism were 24.0% and 19.8% as compared to 12.4% (p = 0.031) and 11.6% (p = 0.13) in the 121 patients that tested negative (COVID-19-). In COVID-19+ patients, we found pronounced increases in plasma levels of von Willebrand factor (vWF) and fibrinogen. Excess mortality was observed in COVID-19+ patients with the following aberrations in hemostatic markers: high D-dimer, low antithrombin or low plasmin-antiplasmin"],"journal":["Thrombosis research"],"pubmed_title":["Associations between hemostatic markers and mortality in COVID-19 - Compounding effects of D-dimer, antithrombin and PAP complex."],"pmcid":["PMC8930184"],"funding_grant_id":["2019-0370"],"pubmed_authors":["Boknas N","Laine C","Gustafsson KM","Lindahl TL","Holmstrom M","Macwan AS","Hillarp A"],"additional_accession":[]},"is_claimable":false,"name":"Associations between hemostatic markers and mortality in COVID-19 - Compounding effects of D-dimer, antithrombin and PAP complex.","description":"In this single-center cohort study, we applied a panel of laboratory markers to characterize hemostatic function in 217 consecutive patients that underwent testing for COVID-19 as they were admitted to Linköping University Hospital between April and June 2020. In the 96 patients that tested positive for SARS-CoV-2 (COVID-19+), the cumulative incidences of death and venous thromboembolism were 24.0% and 19.8% as compared to 12.4% (p = 0.031) and 11.6% (p = 0.13) in the 121 patients that tested negative (COVID-19-). In COVID-19+ patients, we found pronounced increases in plasma levels of von Willebrand factor (vWF) and fibrinogen. Excess mortality was observed in COVID-19+ patients with the following aberrations in hemostatic markers: high D-dimer, low antithrombin or low plasmin-antiplasmin","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 May","modification":"2025-04-19T00:50:58.842Z","creation":"2024-10-14T20:17:39.32Z"},"accession":"S-EPMC8930184","cross_references":{"pubmed":["35316719"],"doi":["10.1016/j.thromres.2022.03.013"]}}