biostudies-literatureUnknown2022Zuin M<h4>Aim</h4>To review and compare the PON-1 arylesterase activity between coronary artery disease (CAD) and non-CAD patients.<h4>Methods</h4>Data were obtained by searching MEDLINE and Scopus for all investigations published between January 1, 2000 and March 1, 2021 comparing PON-1 arylesterase activity between CAD and controls.<h4>Results</h4>Twenty studies, based on 5417 patients, met the inclusion criteria and were included in the analysis. A random effect model revealed that PON-1 arylesterase activity was significantly lower in the CAD group compared to controls (SMD = -0.587, 95%CI = -0.776 to -0.339, <i>p</i> < 0.0001, <i>I</i> ² = 92.3%). In CAD patients, the PON-1 arylesterase activity was significantly higher among CAD patients without diabetes mellitus (DM) compared tDisease markers4264314https://www.ebi.ac.uk/biostudies/studies/S-EPMC8930235biostudies-literatureParaoxonase-1 (PON-1) Arylesterase Activity Levels in Patients with Coronary Artery Disease: A Meta-Analysis.PMC8930235Cervellati CPassaro ABosi CD'Amuri AMarsillach JZuin MZuliani GTrentini ARoncon LMackness MfalseParaoxonase-1 (PON-1) Arylesterase Activity Levels in Patients with Coronary Artery Disease: A Meta-Analysis.<h4>Aim</h4>To review and compare the PON-1 arylesterase activity between coronary artery disease (CAD) and non-CAD patients.<h4>Methods</h4>Data were obtained by searching MEDLINE and Scopus for all investigations published between January 1, 2000 and March 1, 2021 comparing PON-1 arylesterase activity between CAD and controls.<h4>Results</h4>Twenty studies, based on 5417 patients, met the inclusion criteria and were included in the analysis. A random effect model revealed that PON-1 arylesterase activity was significantly lower in the CAD group compared to controls (SMD = -0.587, 95%CI = -0.776 to -0.339, <i>p</i> < 0.0001, <i>I</i> ² = 92.3%). In CAD patients, the PON-1 arylesterase activity was significantly higher among CAD patients without diabetes mellitus (DM) compared t2022-01-01T00:00:00Z20222025-04-04T20:23:35.523Z2025-04-04T20:23:35.523ZS-EPMC89302353530814210.1155/2022/4264314