{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["29(3)"],"submitter":["Stsiapanava A"],"pubmed_abstract":["Glycoprotein 2 (GP2) and uromodulin (UMOD) filaments protect against gastrointestinal and urinary tract infections by acting as decoys for bacterial fimbrial lectin FimH. By combining AlphaFold2 predictions with X-ray crystallography and cryo-EM, we show that these proteins contain a bipartite decoy module whose new fold presents the high-mannose glycan recognized by FimH. The structure rationalizes UMOD mutations associated with kidney diseases and visualizes a key epitope implicated in cast nephropathy."],"journal":["Nature structural & molecular biology"],"pagination":["190-193"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8930769"],"repository":["biostudies-literature"],"pubmed_title":["Structure of the decoy module of human glycoprotein 2 and uromodulin and its interaction with bacterial adhesin FimH."],"pmcid":["PMC8930769"],"pubmed_authors":["Carroni M","de Sanctis D","Tunyasuvunakool K","Han L","Xu C","Wu B","Jovine L","Nishio S","Stsiapanava A","Yamakawa N","Jumper J"],"additional_accession":[]},"is_claimable":false,"name":"Structure of the decoy module of human glycoprotein 2 and uromodulin and its interaction with bacterial adhesin FimH.","description":"Glycoprotein 2 (GP2) and uromodulin (UMOD) filaments protect against gastrointestinal and urinary tract infections by acting as decoys for bacterial fimbrial lectin FimH. By combining AlphaFold2 predictions with X-ray crystallography and cryo-EM, we show that these proteins contain a bipartite decoy module whose new fold presents the high-mannose glycan recognized by FimH. The structure rationalizes UMOD mutations associated with kidney diseases and visualizes a key epitope implicated in cast nephropathy.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2024-10-16T15:03:40.435Z","creation":"2024-10-16T15:03:40.435Z"},"accession":"S-EPMC8930769","cross_references":{"pubmed":["35273390"],"doi":["10.1038/s41594-022-00729-3"]}}