{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Aghanoori MR"],"funding":["Research Manitoba Postdoctoral Fellowship","University of Manitoba Graduate Fellowship","Bank of Montreal (BMO) Financial Group","Canadian Institute of Health Research"],"pagination":["193"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8930798"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["79(4)"],"pubmed_abstract":["Aberrant insulin-like growth factor 1 (IGF-1) signaling has been proposed as a contributing factor to the development of neurodegenerative disorders including diabetic neuropathy, and delivery of exogenous IGF-1 has been explored as a treatment for Alzheimer's disease and amyotrophic lateral sclerosis. However, the role of autocrine/paracrine IGF-1 in neuroprotection has not been well established. We therefore used in vitro cell culture systems and animal models of diabetic neuropathy to characterize endogenous IGF-1 in sensory neurons and determine the factors regulating IGF-1 expression and/or affecting neuronal health. Single-cell RNA sequencing (scRNA-Seq) and in situ hybridization analyses revealed high expression of endogenous IGF-1 in non-peptidergic neurons and satellite glial cell"],"journal":["Cellular and molecular life sciences : CMLS"],"pubmed_title":["CEBPβ regulation of endogenous IGF-1 in adult sensory neurons can be mobilized to overcome diabetes-induced deficits in bioenergetics and axonal outgrowth."],"pmcid":["PMC8930798"],"funding_grant_id":["MOP-130282"],"pubmed_authors":["Lee S","Gauvin E","Agarwal P","Smith DR","Jones MJ","Aghanoori MR","Bonomo R","Miller DW","Fernyhough P","Hai Y","Dolinsky VW","Czubryt MP","Mansuy-Aubert V","Nagalingam RS","Jolivalt CG","Yathindranath V","Calcutt NA"],"additional_accession":[]},"is_claimable":false,"name":"CEBPβ regulation of endogenous IGF-1 in adult sensory neurons can be mobilized to overcome diabetes-induced deficits in bioenergetics and axonal outgrowth.","description":"Aberrant insulin-like growth factor 1 (IGF-1) signaling has been proposed as a contributing factor to the development of neurodegenerative disorders including diabetic neuropathy, and delivery of exogenous IGF-1 has been explored as a treatment for Alzheimer's disease and amyotrophic lateral sclerosis. However, the role of autocrine/paracrine IGF-1 in neuroprotection has not been well established. We therefore used in vitro cell culture systems and animal models of diabetic neuropathy to characterize endogenous IGF-1 in sensory neurons and determine the factors regulating IGF-1 expression and/or affecting neuronal health. Single-cell RNA sequencing (scRNA-Seq) and in situ hybridization analyses revealed high expression of endogenous IGF-1 in non-peptidergic neurons and satellite glial cell","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2026-03-31T11:40:50.641Z","creation":"2024-11-09T21:42:51.372Z"},"accession":"S-EPMC8930798","cross_references":{"pubmed":["35298717"],"doi":["10.1007/s00018-022-04201-9"]}}