{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["12"],"submitter":["Ma XM"],"funding":["National Natural Science Foundation of China","Natural Science Foundation of Guangdong Province"],"pubmed_abstract":["Immunotherapy targeting programmed death ligand-1/programmed cell death protein-1 (PD-L1/PD-1) has achieved great success in multiple cancers, but only a small subset of patients showed clinical responses. Recent evidences have shown that post-translational modification of PD-L1 protein could regulate its protein stability and interaction with cognate receptor PD-1, thereby affecting anticancer immunotherapy in several solid tumors. However, the molecular mechanisms underlying how PD-1/PD-L1 expression is regulated still remain unclear in nasopharyngeal carcinoma (NPC). Here, we found N-glycosylation of PD-L1 in NPC cells and tissues. Mechanistically, we showed that STT3A transferred N-linked glycans to PD-L1, and TGF-β1 could positively regulate STT3A expression through activating c-Jun t"],"journal":["Frontiers in oncology"],"pagination":["815437"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8930841"],"repository":["biostudies-literature"],"pubmed_title":["TGF-β1-Mediated PD-L1 Glycosylation Contributes to Immune Escape <i>via</i> c-Jun/STT3A Pathway in Nasopharyngeal Carcinoma."],"pmcid":["PMC8930841"],"pubmed_authors":["Liu X","Su C","Luo YF","Li XP","Lu J","Ma XM","Zeng FF"],"additional_accession":[]},"is_claimable":false,"name":"TGF-β1-Mediated PD-L1 Glycosylation Contributes to Immune Escape <i>via</i> c-Jun/STT3A Pathway in Nasopharyngeal Carcinoma.","description":"Immunotherapy targeting programmed death ligand-1/programmed cell death protein-1 (PD-L1/PD-1) has achieved great success in multiple cancers, but only a small subset of patients showed clinical responses. Recent evidences have shown that post-translational modification of PD-L1 protein could regulate its protein stability and interaction with cognate receptor PD-1, thereby affecting anticancer immunotherapy in several solid tumors. However, the molecular mechanisms underlying how PD-1/PD-L1 expression is regulated still remain unclear in nasopharyngeal carcinoma (NPC). Here, we found N-glycosylation of PD-L1 in NPC cells and tissues. Mechanistically, we showed that STT3A transferred N-linked glycans to PD-L1, and TGF-β1 could positively regulate STT3A expression through activating c-Jun t","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-06T19:26:04.18Z","creation":"2025-04-06T19:26:04.18Z"},"accession":"S-EPMC8930841","cross_references":{"pubmed":["35311117"],"doi":["10.3389/fonc.2022.815437"]}}