{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["5(1)"],"submitter":["Smyth LCD"],"pubmed_abstract":["Platelet-derived growth factor-BB (PDGF-BB):PDGF receptor-β (PDGFRβ) signalling in brain pericytes is critical to the development, maintenance and function of a healthy blood-brain barrier (BBB). Furthermore, BBB impairment and pericyte loss in Alzheimer's disease (AD) is well documented. We found that PDGF-BB:PDGFRβ signalling components were altered in human AD brains, with a marked reduction in vascular PDGFB. We hypothesised that reduced PDGF-BB:PDGFRβ signalling in pericytes may impact on the BBB. We therefore tested the effects of PDGF-BB on primary human brain pericytes in vitro to define pathways related to BBB function. Using pharmacological inhibitors, we dissected distinct aspects of the PDGF-BB response that are controlled by extracellular signal-regulated kinase (ERK) and Akt "],"journal":["Communications biology"],"pagination":["235"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8931009"],"repository":["biostudies-literature"],"pubmed_title":["Characterisation of PDGF-BB:PDGFRβ signalling pathways in human brain pericytes: evidence of disruption in Alzheimer's disease."],"pmcid":["PMC8931009"],"pubmed_authors":["Wu J","Correia J","Heppner P","Faull RLM","Handley R","Mee EW","Johnson R","Coppieters N","Schweder P","Turner C","Tan A","Curtis MA","Li S","Singh-Bains MK","Jansson D","Rustenhoven J","Dragunow M","Narayan P","Park TI","Highet B","Aalderink M","Smyth LCD"],"additional_accession":[]},"is_claimable":false,"name":"Characterisation of PDGF-BB:PDGFRβ signalling pathways in human brain pericytes: evidence of disruption in Alzheimer's disease.","description":"Platelet-derived growth factor-BB (PDGF-BB):PDGF receptor-β (PDGFRβ) signalling in brain pericytes is critical to the development, maintenance and function of a healthy blood-brain barrier (BBB). Furthermore, BBB impairment and pericyte loss in Alzheimer's disease (AD) is well documented. We found that PDGF-BB:PDGFRβ signalling components were altered in human AD brains, with a marked reduction in vascular PDGFB. We hypothesised that reduced PDGF-BB:PDGFRβ signalling in pericytes may impact on the BBB. We therefore tested the effects of PDGF-BB on primary human brain pericytes in vitro to define pathways related to BBB function. Using pharmacological inhibitors, we dissected distinct aspects of the PDGF-BB response that are controlled by extracellular signal-regulated kinase (ERK) and Akt ","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2026-05-10T01:37:54.519Z","creation":"2025-02-19T01:11:28.779Z"},"accession":"S-EPMC8931009","cross_references":{"pubmed":["35301433"],"doi":["10.1038/s42003-022-03180-8"]}}