{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Sepulveda C"],"funding":["Deutsche Forschungsgemeinschaft","NSF | BIO | Division of Integrative Organismal Systems","Australian Research Council"],"pagination":["e2112820119"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8931227"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["119(11)"],"pubmed_abstract":["SignificanceKarrikins are chemicals in smoke that stimulate regrowth of many plants after fire. However, karrikin responses are not limited to species from fire-prone environments and can affect growth after germination. Putatively, this is because karrikins mimic an unknown signal in plants, KAI2 ligand (KL). Karrikins likely require modification in plants to become bioactive. We identify a gene, <i>KUF1</i>, that appears to negatively regulate biosynthesis of KL and metabolism of a specific karrikin. <i>KUF1</i> expression increases in response to karrikin or KL signaling, thus forming a negative feedback loop that limits further activation of the signaling pathway. This discovery will advance understanding of how karrikins are perceived and how smoke-activated germination evolved. It wi"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["KARRIKIN UP-REGULATED F-BOX 1 (KUF1) imposes negative feedback regulation of karrikin and KAI2 ligand metabolism in <i>Arabidopsis thaliana</i>."],"pmcid":["PMC8931227"],"funding_grant_id":["GU1423/1-1","1856741","DP21013078","1856452"],"pubmed_authors":["Sepulveda C","Guzman MA","Waters MT","Villaecija-Aguilar JA","Gendron JM","Khosla A","Martinez SE","Li Q","Gutjahr C","Kamran M","Liu W","Nelson DC"],"additional_accession":[]},"is_claimable":false,"name":"KARRIKIN UP-REGULATED F-BOX 1 (KUF1) imposes negative feedback regulation of karrikin and KAI2 ligand metabolism in <i>Arabidopsis thaliana</i>.","description":"SignificanceKarrikins are chemicals in smoke that stimulate regrowth of many plants after fire. However, karrikin responses are not limited to species from fire-prone environments and can affect growth after germination. Putatively, this is because karrikins mimic an unknown signal in plants, KAI2 ligand (KL). Karrikins likely require modification in plants to become bioactive. We identify a gene, <i>KUF1</i>, that appears to negatively regulate biosynthesis of KL and metabolism of a specific karrikin. <i>KUF1</i> expression increases in response to karrikin or KL signaling, thus forming a negative feedback loop that limits further activation of the signaling pathway. This discovery will advance understanding of how karrikins are perceived and how smoke-activated germination evolved. It wi","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-27T01:10:35.122Z","creation":"2025-04-06T18:08:14.129Z"},"accession":"S-EPMC8931227","cross_references":{"pubmed":["35254909"],"doi":["10.1073/pnas.2112820119"]}}