{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Gil-Galvez A"],"funding":["European Research Council"],"pagination":["e2114802119"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8931241"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["119(11)"],"pubmed_abstract":["SignificanceIn this manuscript, we address an essential question in developmental and evolutionary biology: How have changes in gene regulatory networks contributed to the invertebrate-to-vertebrate transition? To address this issue, we perturbed four signaling pathways critical for body plan formation in the cephalochordate amphioxus and in zebrafish and compared the effects of such perturbations on gene expression and gene regulation in both species. Our data reveal that many developmental genes have gained response to these signaling pathways in the vertebrate lineage. Moreover, we show that the interconnectivity between these pathways is much higher in zebrafish than in amphioxus. We conclude that this increased signaling pathway complexity likely contributed to vertebrate morphologica"],"journal":["Proceedings of the National Academy of Sciences of the United States of America"],"pubmed_title":["Gain of gene regulatory network interconnectivity at the origin of vertebrates."],"pmcid":["PMC8931241"],"funding_grant_id":["740041"],"pubmed_authors":["Gil-Galvez A","Tena JJ","Bertrand S","Acemel RD","Su YH","Chou C","Gomez-Skarmeta JL","Lin CY","Perez-Posada A","Schubert M","Escriva H","Franke M","Yu JK","Jimenez-Gancedo S"],"additional_accession":[]},"is_claimable":false,"name":"Gain of gene regulatory network interconnectivity at the origin of vertebrates.","description":"SignificanceIn this manuscript, we address an essential question in developmental and evolutionary biology: How have changes in gene regulatory networks contributed to the invertebrate-to-vertebrate transition? To address this issue, we perturbed four signaling pathways critical for body plan formation in the cephalochordate amphioxus and in zebrafish and compared the effects of such perturbations on gene expression and gene regulation in both species. Our data reveal that many developmental genes have gained response to these signaling pathways in the vertebrate lineage. Moreover, we show that the interconnectivity between these pathways is much higher in zebrafish than in amphioxus. We conclude that this increased signaling pathway complexity likely contributed to vertebrate morphologica","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-27T01:00:25.372Z","creation":"2025-04-06T18:07:26.376Z"},"accession":"S-EPMC8931241","cross_references":{"pubmed":["35263228"],"doi":["10.1073/pnas.2114802119"]}}