{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Hishida T"],"funding":["NINDS NIH HHS","NIGMS NIH HHS"],"pagination":["786031"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8931341"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["10"],"pubmed_abstract":["It is widely believed that cellular senescence plays a critical role in both aging and cancer, and that senescence is a fundamental, permanent growth arrest that somatic cells cannot avoid. Here we show that Myc plays an important role in self-renewal of esophageal epithelial cells, contributing to their resistance to cellular senescence. Myc is homogeneously expressed in basal cells of the esophageal epithelium and Myc positively regulates their self-renewal by maintaining their undifferentiated state. Indeed, Myc knockout induced a loss of the undifferentiated state of esophageal epithelial cells resulting in cellular senescence while forced MYC expression promoted oncogenic cell proliferation. A superoxide scavenger counteracted Myc knockout-induced senescence, therefore suggesting that"],"journal":["Frontiers in cell and developmental biology"],"pubmed_title":["Myc Supports Self-Renewal of Basal Cells in the Esophageal Epithelium."],"pmcid":["PMC8931341"],"funding_grant_id":["R01 NS106878","R01 GM116919"],"pubmed_authors":["Sahu SK","O'Keefe DD","Hishida-Nozaki Y","Nunez Delicado E","Kato R","Izpisua Belmonte JC","Hatanaka F","Yoshida K","Rodriguez Esteban C","Takahashi Y","Knoepfler PS","Nakagawa H","Takemoto Y","Castells A","Hishida T","Vazquez-Ferrer E","Prieto J","Reddy P","Campistol JM"],"additional_accession":[]},"is_claimable":false,"name":"Myc Supports Self-Renewal of Basal Cells in the Esophageal Epithelium.","description":"It is widely believed that cellular senescence plays a critical role in both aging and cancer, and that senescence is a fundamental, permanent growth arrest that somatic cells cannot avoid. Here we show that Myc plays an important role in self-renewal of esophageal epithelial cells, contributing to their resistance to cellular senescence. Myc is homogeneously expressed in basal cells of the esophageal epithelium and Myc positively regulates their self-renewal by maintaining their undifferentiated state. Indeed, Myc knockout induced a loss of the undifferentiated state of esophageal epithelial cells resulting in cellular senescence while forced MYC expression promoted oncogenic cell proliferation. A superoxide scavenger counteracted Myc knockout-induced senescence, therefore suggesting that","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-04T14:50:07.481Z","creation":"2025-04-04T14:50:07.481Z"},"accession":"S-EPMC8931341","cross_references":{"pubmed":["35309931"],"doi":["10.3389/fcell.2022.786031"]}}