biostudies-literatureUnknown22(1)Lam J<h4>Background</h4>Over the past two decades, prescription medication use for pain and depression increased dramatically. Most studies consider the early life course, despite a similar increase among those in later life. In this paper, we examine whether and how later life transitions may relate to changes in medication use.<h4>Methods</h4>We draw on data from the Health and Retirement Study and fixed-effects models to examine whether work, family, and civic transitions in later life are related to changes in the usage of prescription pain and depression medication.<h4>Results</h4>Results show that individuals had higher odds of regularly using prescription pain and depression medications in periods when out of the labor market. Higher odds of depression medication use were also associatedBMC geriatrics222https://www.ebi.ac.uk/biostudies/studies/S-EPMC8931979biostudies-literatureLater-life transitions and changes in prescription medication use for pain and depression.PMC8931979Vuolo MLam JfalseLater-life transitions and changes in prescription medication use for pain and depression.<h4>Background</h4>Over the past two decades, prescription medication use for pain and depression increased dramatically. Most studies consider the early life course, despite a similar increase among those in later life. In this paper, we examine whether and how later life transitions may relate to changes in medication use.<h4>Methods</h4>We draw on data from the Health and Retirement Study and fixed-effects models to examine whether work, family, and civic transitions in later life are related to changes in the usage of prescription pain and depression medication.<h4>Results</h4>Results show that individuals had higher odds of regularly using prescription pain and depression medications in periods when out of the labor market. Higher odds of depression medication use were also associated2022-01-01T00:00:00Z2022 Mar2025-04-04T08:24:36.13Z2025-04-04T08:24:36.13ZS-EPMC89319793530060210.1186/s12877-022-02921-y