{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Tu CF"],"funding":["Institute of Biomedical Sciences","Ministry of Science and Technology, Taiwan","Academia Sinica, Taiwan"],"pagination":["21"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8932202"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["24(1)"],"pubmed_abstract":["<h4>Background</h4>We recently showed that fucosyltransferase 8 (FUT8)-mediated core fucosylation of transforming growth factor-β receptor enhances its signaling and promotes breast cancer invasion and metastasis. However, the complete FUT8 target glycoproteins and their downstream signaling networks critical for breast cancer progression remain largely unknown.<h4>Method</h4>We performed quantitative glycoproteomics with two highly invasive breast cancer cell lines to unravel a comprehensive list of core-fucosylated glycoproteins by comparison to parental wild-type and FUT8-knockout counterpart cells. In addition, ingenuity pathway analysis (IPA) was performed to highlight the most enriched biological functions and signaling pathways mediated by FUT8 targets. Novel FUT8 target glycoprotei"],"journal":["Breast cancer research : BCR"],"pubmed_title":["Quantitative glycoproteomics analysis identifies novel FUT8 targets and signaling networks critical for breast cancer cell invasiveness."],"pmcid":["PMC8932202"],"funding_grant_id":["MOST 110-2320-B-001-019-MY3","IBMS-CRC110-P04","AS-KPQ-111-KNT","MOST 107-2320-B-001-015-MY3","MOST 109-2320-B-001-012-MY3","AS-GC-111-L04"],"pubmed_authors":["Li LH","Li FA","Yang RB","Tu CF"],"additional_accession":[]},"is_claimable":false,"name":"Quantitative glycoproteomics analysis identifies novel FUT8 targets and signaling networks critical for breast cancer cell invasiveness.","description":"<h4>Background</h4>We recently showed that fucosyltransferase 8 (FUT8)-mediated core fucosylation of transforming growth factor-β receptor enhances its signaling and promotes breast cancer invasion and metastasis. However, the complete FUT8 target glycoproteins and their downstream signaling networks critical for breast cancer progression remain largely unknown.<h4>Method</h4>We performed quantitative glycoproteomics with two highly invasive breast cancer cell lines to unravel a comprehensive list of core-fucosylated glycoproteins by comparison to parental wild-type and FUT8-knockout counterpart cells. In addition, ingenuity pathway analysis (IPA) was performed to highlight the most enriched biological functions and signaling pathways mediated by FUT8 targets. Novel FUT8 target glycoprotei","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-26T18:31:30.425Z","creation":"2025-04-06T15:49:28.44Z"},"accession":"S-EPMC8932202","cross_references":{"pubmed":["35303925"],"doi":["10.1186/s13058-022-01513-3"]}}