{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["8(11)"],"submitter":["Niu M"],"pubmed_abstract":["The processing of stress responses involves brain-wide communication among cortical and subcortical regions; however, the underlying mechanisms remain elusive. Here, we show that the claustrum (CLA) is crucial for the control of stress-induced anxiety-related behaviors. A combined approach using brain activation mapping and machine learning showed that the CLA activation serves as a reliable marker of exposure to acute stressors. In TRAP2 mice, which allow activity-dependent genetic labeling, chemogenetic activation of the CLA neuronal ensemble tagged by acute social defeat stress (DS) elicited anxiety-related behaviors, whereas silencing of the CLA ensemble attenuated DS-induced anxiety-related behaviors. Moreover, the CLA received strong input from DS-activated basolateral amygdala neuro"],"journal":["Science advances"],"pagination":["eabi6375"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8932664"],"repository":["biostudies-literature"],"pubmed_title":["Claustrum mediates bidirectional and reversible control of stress-induced anxiety responses."],"pmcid":["PMC8932664"],"pubmed_authors":["Seiriki K","Ohkubo J","Tanuma M","Yokoyama R","Tanabe W","Miyaji K","Okuno H","Ago Y","Inoue KI","Nakazawa T","Nagayasu K","Seo K","Kuwaki T","Kaneko S","Yamaguchi S","Hayashida M","Takada M","Igarashi H","Ueno H","Yamanaka A","Niu M","Kasai A","Hashimoto H"],"additional_accession":[]},"is_claimable":false,"name":"Claustrum mediates bidirectional and reversible control of stress-induced anxiety responses.","description":"The processing of stress responses involves brain-wide communication among cortical and subcortical regions; however, the underlying mechanisms remain elusive. Here, we show that the claustrum (CLA) is crucial for the control of stress-induced anxiety-related behaviors. A combined approach using brain activation mapping and machine learning showed that the CLA activation serves as a reliable marker of exposure to acute stressors. In TRAP2 mice, which allow activity-dependent genetic labeling, chemogenetic activation of the CLA neuronal ensemble tagged by acute social defeat stress (DS) elicited anxiety-related behaviors, whereas silencing of the CLA ensemble attenuated DS-induced anxiety-related behaviors. Moreover, the CLA received strong input from DS-activated basolateral amygdala neuro","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-04T03:20:21.846Z","creation":"2025-04-04T03:20:21.846Z"},"accession":"S-EPMC8932664","cross_references":{"pubmed":["35302853"],"doi":["10.1126/sciadv.abi6375"]}}