biostudies-literatureUnknown11Sitohang NA<b>Background</b>: Phytomedicines are gaining a spotlight in wound management, where much research has suggested the wound healing potential of <i>Barringtonia racemosa</i>. The objective of this study was to investigate the effectiveness of <i>B. racemosa</i> kernel extract in accelerating wound healing process in animal models. <b>Methods:</b> <i>B. racemosa</i> kernel was extracted using ethanol:water (7:3) solvent and was then used as a bioactive ingredient in a Carbopol 940-based gel formulation in four different concentrations (1, 3, 5 and 7 ppm). A 3 cm diameter wound was made in the dorsal area of <i>Rattus norvegicus</i> rat and wound healing process was assessed up to 12 days using DESIGN (Depth, Exudate, Size of Inflammation/Infection, Granulation tissue, and Necrotic tissue) scoring system. <b>Results:</b> Our data suggested that the DESIGN scores were significantly different among concentration groups after the 3 ^rdday onward suggesting <i>B. racemosa</i> extract accelerated the wound healing process. Rats treated with gel formulation containing 7 ppm of <i>B. racemosa</i> kernel extract had faster wound healing than that treated with topical Metcovazin. On day 6, macroscopic observation on 7 ppm group revealed that the wound had persistent redness, lesion area of < 3 cm ², and 80% healthy granulation, where presence of exudate and redness were not observable. <b>Conclusion:</b> <i>B. racemosa</i> kernel extract was effective in accelerating wound healing on rats. Further study is warranted to purify the bioactive component and the action mechanism in wound healing process.F1000Research191https://www.ebi.ac.uk/biostudies/studies/S-EPMC8933646biostudies-literatureAcceleration of wound healing by topical application of gel formulation of <i>Barringtonia racemosa</i> (L.) Spreng kernel extract.PMC8933646Musman MSitohang NAPutra EDLKamil HfalseAcceleration of wound healing by topical application of gel formulation of <i>Barringtonia racemosa</i> (L.) Spreng kernel extract.<b>Background</b>: Phytomedicines are gaining a spotlight in wound management, where much research has suggested the wound healing potential of <i>Barringtonia racemosa</i>. The objective of this study was to investigate the effectiveness of <i>B. racemosa</i> kernel extract in accelerating wound healing process in animal models. <b>Methods:</b> <i>B. racemosa</i> kernel was extracted using ethanol:water (7:3) solvent and was then used as a bioactive ingredient in a Carbopol 940-based gel formulation in four different concentrations (1, 3, 5 and 7 ppm). A 3 cm diameter wound was made in the dorsal area of <i>Rattus norvegicus</i> rat and wound healing process was assessed up to 12 days using DESIGN (Depth, Exudate, Size of Inflammation/Infection, Granulation tissue, and Necrotic tissue) scoring system. <b>Results:</b> Our data suggested that the DESIGN scores were significantly different among concentration groups after the 3 ^rdday onward suggesting <i>B. racemosa</i> extract accelerated the wound healing process. Rats treated with gel formulation containing 7 ppm of <i>B. racemosa</i> kernel extract had faster wound healing than that treated with topical Metcovazin. On day 6, macroscopic observation on 7 ppm group revealed that the wound had persistent redness, lesion area of < 3 cm ², and 80% healthy granulation, where presence of exudate and redness were not observable. <b>Conclusion:</b> <i>B. racemosa</i> kernel extract was effective in accelerating wound healing on rats. Further study is warranted to purify the bioactive component and the action mechanism in wound healing process.2022-01-01T00:00:00Z20222025-04-04T23:01:50.882Z2025-04-04T23:01:50.882ZS-EPMC89336463535631310.12688/f1000research.104602.2