biostudies-literatureZhao XNational Natural Science Foundation of Chinae2484https://www.ebi.ac.uk/biostudies/studies/S-EPMC8933759biostudies-literatureUnknown12(3)<h4>Introduction</h4>The differences of functional connectivity (FC) and functional asymmetry between left and right mesial temporal lobe epilepsy with hippocampal sclerosis (LMTLE and RMTLE) have not been completely clarified yet. The purpose of the present study is to investigate the FC changes and the FC asymmetric patterns of MTLE, and to compare the differences in FC and functional asymmetry between LMTLE and RMTLE.<h4>Methods</h4>In total, 12 LMTLE, 11 RMTLE patients, and 23 healthy controls (HC) were included. Region of interest (ROI)-based analysis was used to evaluate FC. The right functional connectivity (rFC) and left functional connectivity (lFC) of each ROI were calculated. Asymmetry index (AI) was calculated based on the following formula: AI=100×(rFC-lFC)/[(rFC+lFC)/2]${\rm{Brain and behaviorInterhemispheric functional connectivity asymmetry is distinctly affected in left and right mesial temporal lobe epilepsy.PMC8933759819742798173004981570462Kang HLi JHu YLi SZhu WZhao XZhou ZfalseInterhemispheric functional connectivity asymmetry is distinctly affected in left and right mesial temporal lobe epilepsy.<h4>Introduction</h4>The differences of functional connectivity (FC) and functional asymmetry between left and right mesial temporal lobe epilepsy with hippocampal sclerosis (LMTLE and RMTLE) have not been completely clarified yet. The purpose of the present study is to investigate the FC changes and the FC asymmetric patterns of MTLE, and to compare the differences in FC and functional asymmetry between LMTLE and RMTLE.<h4>Methods</h4>In total, 12 LMTLE, 11 RMTLE patients, and 23 healthy controls (HC) were included. Region of interest (ROI)-based analysis was used to evaluate FC. The right functional connectivity (rFC) and left functional connectivity (lFC) of each ROI were calculated. Asymmetry index (AI) was calculated based on the following formula: AI=100×(rFC-lFC)/[(rFC+lFC)/2]${\rm{2022-01-01T00:00:00Z2022 Mar2025-04-21T23:17:27.58Z2025-04-05T19:05:50.374ZS-EPMC89337593516607210.1002/brb3.2484