{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Murugan K"],"funding":["Ministry of Science and Technology, Taiwan","Center of Excellence for Ocean Engineering, NTOU, Taiwan"],"pagination":["4765"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8933857"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["12(1)"],"pubmed_abstract":["Mosquito borne diseases are on the rise because of their fast spread worldwide and the lack of effective treatments. Here we are focusing on the development of a novel anti-malarial and virucidal agent with biocidal effects also on its vectors. We have synthesized a new quinoline (4,7-dichloroquinoline) derivative which showed significant larvicidal and pupicidal properties against a malarial and a dengue vector and a lethal toxicity ranging from 4.408 µM/mL (first instar larvae) to 7.958 µM/mL (pupal populations) for Anopheles stephensi and 5.016 µM/mL (larva 1) to 10.669 µM/mL (pupae) for Aedes aegypti. In-vitro antiplasmodial efficacy of 4,7-dichloroquinoline revealed a significant growth inhibition of both sensitive strains of Plasmodium falciparum with IC<sub>50</sub> values of 6.7 nM"],"journal":["Scientific reports"],"pubmed_title":["Synthesis of new series of quinoline derivatives with insecticidal effects on larval vectors of malaria and dengue diseases."],"pmcid":["PMC8933857"],"funding_grant_id":["MOST 109-2621-M-019-002","109J13801-51","MOST 110-2621-M-019-001","110J13801-51","MOST 108-2621-M-019-003"],"pubmed_authors":["Hwang JS","Portilla-Pulido JS","Mendez SC","Paulpandi M","Aziz AT","Rajaganesh R","Vasanthakumaran M","Shafi SS","Dinesh D","Wang L","Duque JE","Murugan K","Madhavan J","Panneerselvam C","Subramaniam J","Roni M","Chandramohan B","Piramanayagam S"],"additional_accession":[]},"is_claimable":false,"name":"Synthesis of new series of quinoline derivatives with insecticidal effects on larval vectors of malaria and dengue diseases.","description":"Mosquito borne diseases are on the rise because of their fast spread worldwide and the lack of effective treatments. Here we are focusing on the development of a novel anti-malarial and virucidal agent with biocidal effects also on its vectors. We have synthesized a new quinoline (4,7-dichloroquinoline) derivative which showed significant larvicidal and pupicidal properties against a malarial and a dengue vector and a lethal toxicity ranging from 4.408 µM/mL (first instar larvae) to 7.958 µM/mL (pupal populations) for Anopheles stephensi and 5.016 µM/mL (larva 1) to 10.669 µM/mL (pupae) for Aedes aegypti. In-vitro antiplasmodial efficacy of 4,7-dichloroquinoline revealed a significant growth inhibition of both sensitive strains of Plasmodium falciparum with IC<sub>50</sub> values of 6.7 nM","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-05-31T22:58:40.98Z","creation":"2024-11-11T23:08:13.431Z"},"accession":"S-EPMC8933857","cross_references":{"pubmed":["35306526"],"doi":["10.1038/s41598-022-08397-5"]}}