biostudies-literatureMurugan KMinistry of Science and Technology, TaiwanCenter of Excellence for Ocean Engineering, NTOU, Taiwan4765https://www.ebi.ac.uk/biostudies/studies/S-EPMC8933857biostudies-literatureUnknown12(1)Mosquito borne diseases are on the rise because of their fast spread worldwide and the lack of effective treatments. Here we are focusing on the development of a novel anti-malarial and virucidal agent with biocidal effects also on its vectors. We have synthesized a new quinoline (4,7-dichloroquinoline) derivative which showed significant larvicidal and pupicidal properties against a malarial and a dengue vector and a lethal toxicity ranging from 4.408 µM/mL (first instar larvae) to 7.958 µM/mL (pupal populations) for Anopheles stephensi and 5.016 µM/mL (larva 1) to 10.669 µM/mL (pupae) for Aedes aegypti. In-vitro antiplasmodial efficacy of 4,7-dichloroquinoline revealed a significant growth inhibition of both sensitive strains of Plasmodium falciparum with IC₅₀ values of 6.7 nMScientific reportsSynthesis of new series of quinoline derivatives with insecticidal effects on larval vectors of malaria and dengue diseases.PMC8933857MOST 109-2621-M-019-002109J13801-51MOST 110-2621-M-019-001110J13801-51MOST 108-2621-M-019-003Hwang JSPortilla-Pulido JSMendez SCPaulpandi MAziz ATRajaganesh RVasanthakumaran MShafi SSDinesh DWang LDuque JEMurugan KMadhavan JPanneerselvam CSubramaniam JRoni MChandramohan BPiramanayagam SfalseSynthesis of new series of quinoline derivatives with insecticidal effects on larval vectors of malaria and dengue diseases.Mosquito borne diseases are on the rise because of their fast spread worldwide and the lack of effective treatments. Here we are focusing on the development of a novel anti-malarial and virucidal agent with biocidal effects also on its vectors. We have synthesized a new quinoline (4,7-dichloroquinoline) derivative which showed significant larvicidal and pupicidal properties against a malarial and a dengue vector and a lethal toxicity ranging from 4.408 µM/mL (first instar larvae) to 7.958 µM/mL (pupal populations) for Anopheles stephensi and 5.016 µM/mL (larva 1) to 10.669 µM/mL (pupae) for Aedes aegypti. In-vitro antiplasmodial efficacy of 4,7-dichloroquinoline revealed a significant growth inhibition of both sensitive strains of Plasmodium falciparum with IC₅₀ values of 6.7 nM2022-01-01T00:00:00Z2022 Mar2025-05-31T22:58:40.98Z2024-11-11T23:08:13.431ZS-EPMC89338573530652610.1038/s41598-022-08397-5