biostudies-literatureRahman MMU.S. Environmental Protection AgencyNIEHS NIH HHSNHLBI NIH HHSNational Institutes of Health36https://www.ebi.ac.uk/biostudies/studies/S-EPMC8933931biostudies-literatureUnknown21(1)<h4>Background</h4>Air pollution has been associated with metabolic disease and obesity. Adipokines are potential mediators of these effects, but studies of air pollution-adipokine relationships are inconclusive. Macrophage and T cells in adipose tissue (AT) and blood modulate inflammation; however, the role of immune cells in air pollution-induced dysregulation of adipokines has not been studied. We examined the association between air pollution exposure and circulating and AT adipokine concentrations, and whether these relationships were modified by macrophage and T cell numbers in the blood and AT.<h4>Methods</h4>Fasting blood and abdominal subcutaneous AT biopsies were collected from 30 overweight/obese 18-26 year-old volunteers. Flow cytometry was used to quantify T effector (Teff, inEnvironmental health : a global access science sourceNear-roadway air pollution, immune cells and adipokines among obese young adults.PMC8933931R01 ES025786R01 HL151493R21ES024707RD-83544101P30ES007048P01ES022845R01ES025786R01 HL144790P30 ES007048R01 HL159804P01 ES022845R21 ES024707Rahman MMAkbari OSankaranarayanan ILiu FFShafiei-Jahani PMcConnell REckel SPSattler FLurmann FWHoward EBaronikian LAllayee HfalseNear-roadway air pollution, immune cells and adipokines among obese young adults.<h4>Background</h4>Air pollution has been associated with metabolic disease and obesity. Adipokines are potential mediators of these effects, but studies of air pollution-adipokine relationships are inconclusive. Macrophage and T cells in adipose tissue (AT) and blood modulate inflammation; however, the role of immune cells in air pollution-induced dysregulation of adipokines has not been studied. We examined the association between air pollution exposure and circulating and AT adipokine concentrations, and whether these relationships were modified by macrophage and T cell numbers in the blood and AT.<h4>Methods</h4>Fasting blood and abdominal subcutaneous AT biopsies were collected from 30 overweight/obese 18-26 year-old volunteers. Flow cytometry was used to quantify T effector (Teff, in2022-01-01T00:00:00Z2022 Mar2025-04-04T13:21:57.478Z2025-04-04T13:21:57.478ZS-EPMC89339313530566310.1186/s12940-022-00842-2