{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Yang M"],"funding":["Guangdong Provincial Promotion Project on Preservation and Utilization of Local Breed of Livestock and Poultry","the Key-Area Research and Development Program of Guangdong Province","the China Agriculture Research System"],"pagination":["219"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8933938"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["23(1)"],"pubmed_abstract":["Background
Adipose tissue is an important endocrine and energy-storage organ in organisms, and it plays a crucial role in the energy-metabolism balance. Previous studies have found that sex-linked dwarf (SLD) chickens generally have excessively high abdominal fat deposition during the growing period, which increases feeding costs. However, the underlying mechanism of this fat deposition during the growth of SLD chickens remains unknown.Results
The Oil Red O staining showed that the lipid-droplet area of SLD chickens was larger than that of normal chickens in E15 and 14d. Consistently, TG content in the livers of SLD chickens was higher than that of normal chickens in E15 and 14d. Further, lower ΔΨm and lower ATP levels and higher MDA levels were observed in SLD chickens tha"],"journal":["BMC genomics"],"pubmed_title":["Growth hormone receptor gene influences mitochondrial function and chicken lipid metabolism by AMPK-PGC1α-PPAR signaling pathway."],"pmcid":["PMC8933938"],"funding_grant_id":["CARS-41-G03","2020B020222002"],"pubmed_authors":["Liao Z","Li H","Shi M","Zhang D","Zhao C","Li D","Yang M","Nie Q","Hu B","Zhao Y","Luo Q","Liang J","Zhang X","Sun D","Wei H"],"additional_accession":[]},"is_claimable":false,"name":"Growth hormone receptor gene influences mitochondrial function and chicken lipid metabolism by AMPK-PGC1α-PPAR signaling pathway.","description":"Background
Adipose tissue is an important endocrine and energy-storage organ in organisms, and it plays a crucial role in the energy-metabolism balance. Previous studies have found that sex-linked dwarf (SLD) chickens generally have excessively high abdominal fat deposition during the growing period, which increases feeding costs. However, the underlying mechanism of this fat deposition during the growth of SLD chickens remains unknown.Results
The Oil Red O staining showed that the lipid-droplet area of SLD chickens was larger than that of normal chickens in E15 and 14d. Consistently, TG content in the livers of SLD chickens was higher than that of normal chickens in E15 and 14d. Further, lower ΔΨm and lower ATP levels and higher MDA levels were observed in SLD chickens tha","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Mar","modification":"2025-04-26T18:27:25.911Z","creation":"2025-04-06T15:49:47.956Z"},"accession":"S-EPMC8933938","cross_references":{"pubmed":["35305578"],"doi":["10.1186/s12864-021-08268-9"]}}