biostudies-literatureAkhabir Lcanada excellence research chairs, government of canadaallergenheart and stroke foundation of canadacanadian institute for health research221https://www.ebi.ac.uk/biostudies/studies/S-EPMC8933946biostudies-literatureUnknown23(1)<h4>Background</h4>Environmental exposures in utero which modify DNA methylation may have a long-lasting impact on health and disease in offspring. We aimed to identify and replicate previously published genomic loci where DNA methylation changes are attributable to in utero exposures in the NutriGen birth cohort studies Alliance.<h4>Methods</h4>We reviewed the literature to identify differentially methylated sites of newborn DNA which are associated with the following five traits of interest maternal diabetes, pre-pregnancy body mass index (BMI), diet during pregnancy, smoking, and gestational age. We then attempted to replicate these published associations in the Canadian Healthy Infant Longitudinal Development (CHILD) and the South Asian birth cohort (START) cord blood epigenome-wide daBMC genomicsDNA methylation changes in cord blood and the developmental origins of health and disease - a systematic review and replication study.PMC8933946canada excellence research chairs, government of canadaallergenINC-109205201301FH6AEC85761NA7283Denburg JALefebvre DLMandhane PJStringer RYusuf Sde Souza RJLou WWilson JAnand SSSears MRMcDonald SAzad MBMente ABecker ABKobor MTeo KKGupta MMoraes TJZulyniak MAPare GNutriGen AllianceMeyre DWahi GMorrison KAkhabir LBrook JSubbarao PAtkinson SDesai DAtkinson SATurvey SEfalseDNA methylation changes in cord blood and the developmental origins of health and disease - a systematic review and replication study.<h4>Background</h4>Environmental exposures in utero which modify DNA methylation may have a long-lasting impact on health and disease in offspring. We aimed to identify and replicate previously published genomic loci where DNA methylation changes are attributable to in utero exposures in the NutriGen birth cohort studies Alliance.<h4>Methods</h4>We reviewed the literature to identify differentially methylated sites of newborn DNA which are associated with the following five traits of interest maternal diabetes, pre-pregnancy body mass index (BMI), diet during pregnancy, smoking, and gestational age. We then attempted to replicate these published associations in the Canadian Healthy Infant Longitudinal Development (CHILD) and the South Asian birth cohort (START) cord blood epigenome-wide da2022-01-01T00:00:00Z2022 Mar2025-04-04T13:21:38.57Z2025-04-04T13:21:38.57ZS-EPMC89339463530557510.1186/s12864-022-08451-6