biostudies-literatureUnknown2022Zhou J<h4>Objectives</h4>Myocardial infarction (MI) is a common cardiovascular disease. Histopathology is a main molecular characteristic of MI, but often, differences between various cell subsets have been neglected. Under this premise, MI-related molecular biomarkers were screened using single-cell sequencing.<h4>Methods</h4>This work examined immune cell abundance in normal and MI samples from GSE109048 and determined differences in the activated mast cells and activated CD4 memory T cells, resting mast cells. Weighted gene coexpression network analysis (WGCNA) demonstrated that activated CD4 memory T cells were the most closely related to the turquoise module, and 10 hub genes were screened. Single-cell sequencing data (scRNA-seq) of MI were examined. We used <i>t</i>-distributed stochastic Computational and mathematical methods in medicine6534126https://www.ebi.ac.uk/biostudies/studies/S-EPMC8934393biostudies-literatureSingle-Cell Sequencing Revealed Pivotal Genes Related to Prognosis of Myocardial Infarction Patients.PMC8934393Peng XZhang WChen ZWei CLi QWen TWei YPeng JZhou JfalseSingle-Cell Sequencing Revealed Pivotal Genes Related to Prognosis of Myocardial Infarction Patients.<h4>Objectives</h4>Myocardial infarction (MI) is a common cardiovascular disease. Histopathology is a main molecular characteristic of MI, but often, differences between various cell subsets have been neglected. Under this premise, MI-related molecular biomarkers were screened using single-cell sequencing.<h4>Methods</h4>This work examined immune cell abundance in normal and MI samples from GSE109048 and determined differences in the activated mast cells and activated CD4 memory T cells, resting mast cells. Weighted gene coexpression network analysis (WGCNA) demonstrated that activated CD4 memory T cells were the most closely related to the turquoise module, and 10 hub genes were screened. Single-cell sequencing data (scRNA-seq) of MI were examined. We used <i>t</i>-distributed stochastic 2022-01-01T00:00:00Z20222025-04-18T15:18:11.302Z2025-02-19T04:20:42.021ZS-EPMC89343933531719410.1155/2022/6534126