{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Kemp CG"],"funding":["NIMH NIH HHS","National Institute of Mental Health"],"pagination":["39-45"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8934572"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["74"],"pubmed_abstract":["<h4>Objective</h4>We assessed the impact of a collaborative care intervention on anxiety symptoms among participants in India with comorbid depression, poorly controlled diabetes, and moderate to severe anxiety symptoms.<h4>Method</h4>We analyzed data from a randomized controlled trial conducted at four diabetes clinics in India. Participants received either collaborative care or usual care. We included only participants who scored ⩾10 on the Generalized Anxiety Disorder-7 (GAD-7) at baseline. We estimated the effect of the intervention on clinically significant reduction in anxiety symptoms; we considered several potential baseline moderators and mediation by anti-depressant use.<h4>Results</h4>One hundred and seventy-two participants scored 10 or above on the GAD-7 at baseline. Collaborative care participants were more likely than control participants to achieve a clinically significant reduction in anxiety symptoms at 6 and 12 months (65.7% vs. 41.4% at 12 months, p = 0.002); these differences were not sustained at 18 or 24 months. There was little evidence of moderation by participant characteristics at baseline, and effects were not mediated by anti-depressant use.<h4>Conclusions</h4>Collaborative care for the treatment of depression and type 2 diabetes can lead to clinically significant reductions in anxiety symptoms among patients with anxiety. Effects were notable during the active intervention period but not over the year post-intervention."],"journal":["General hospital psychiatry"],"pubmed_title":["Effect of a collaborative care model on anxiety symptoms among patients with depression and diabetes in India: The INDEPENDENT randomized clinical trial."],"pmcid":["PMC8934572"],"funding_grant_id":["R01MH100390","R01 MH100390"],"pubmed_authors":["Poongothai S","Kemp CG","Patel SA","Johnson LCM","Ali MK","Anjana RM","Aravind S","Rao D","Chwastiak LA","Sagar R","Mohan V","Tandon N","Emmert-Fees K","Sridhar GR","Narayan KMV"],"additional_accession":[]},"is_claimable":false,"name":"Effect of a collaborative care model on anxiety symptoms among patients with depression and diabetes in India: The INDEPENDENT randomized clinical trial.","description":"<h4>Objective</h4>We assessed the impact of a collaborative care intervention on anxiety symptoms among participants in India with comorbid depression, poorly controlled diabetes, and moderate to severe anxiety symptoms.<h4>Method</h4>We analyzed data from a randomized controlled trial conducted at four diabetes clinics in India. Participants received either collaborative care or usual care. We included only participants who scored ⩾10 on the Generalized Anxiety Disorder-7 (GAD-7) at baseline. We estimated the effect of the intervention on clinically significant reduction in anxiety symptoms; we considered several potential baseline moderators and mediation by anti-depressant use.<h4>Results</h4>One hundred and seventy-two participants scored 10 or above on the GAD-7 at baseline. Collaborative care participants were more likely than control participants to achieve a clinically significant reduction in anxiety symptoms at 6 and 12 months (65.7% vs. 41.4% at 12 months, p = 0.002); these differences were not sustained at 18 or 24 months. There was little evidence of moderation by participant characteristics at baseline, and effects were not mediated by anti-depressant use.<h4>Conclusions</h4>Collaborative care for the treatment of depression and type 2 diabetes can lead to clinically significant reductions in anxiety symptoms among patients with anxiety. Effects were notable during the active intervention period but not over the year post-intervention.","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022 Jan-Feb","modification":"2025-04-21T15:16:32.385Z","creation":"2025-04-21T15:16:32.385Z"},"accession":"S-EPMC8934572","cross_references":{"pubmed":["34883269"],"doi":["10.1016/j.genhosppsych.2021.11.003"]}}