{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"submitter":["Lu Y"],"funding":["NIAID NIH HHS"],"pagination":["858256"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8934864"],"repository":["biostudies-literature"],"omics_type":["Unknown"],"volume":["13"],"pubmed_abstract":["To determine whether aorta becomes immune organ in pathologies, we performed transcriptomic analyses of six types of secretomic genes (SGs) in aorta and vascular cells and made the following findings: 1) 53.7% out of 21,306 human protein genes are classified into six secretomes, namely, canonical, caspase 1, caspase 4, exosome, Weibel-Palade body, and autophagy; 2) Atherosclerosis (AS), chronic kidney disease (CKD) and abdominal aortic aneurysm (AAA) modulate six secretomes in aortas; and Middle East Respiratory Syndrome Coronavirus (MERS-CoV, COVID-19 homologous) infected endothelial cells (ECs) and angiotensin-II (Ang-II) treated vascular smooth muscle cells (VSMCs) modulate six secretomes; 3) AS aortas upregulate T and B cell immune SGs; CKD aortas upregulate SGs for cardiac hypertrophy"],"journal":["Frontiers in immunology"],"pubmed_title":["Aorta in Pathologies May Function as an Immune Organ by Upregulating Secretomes for Immune and Vascular Cell Activation, Differentiation and Trans-Differentiation-Early Secretomes may Serve as Drivers for Trained Immunity."],"pmcid":["PMC8934864"],"funding_grant_id":["R01 AI145034"],"pubmed_authors":["Xu K","Lu Y","Hu W","Saaoud F","Drummer C","Wang H","Yu J","Sun Y","Yang X","Vazquez-Padron RI","Kunapuli SP","Shao Y","Bethea JR","Jiang X","Wu S","Sun J"],"additional_accession":[]},"is_claimable":false,"name":"Aorta in Pathologies May Function as an Immune Organ by Upregulating Secretomes for Immune and Vascular Cell Activation, Differentiation and Trans-Differentiation-Early Secretomes may Serve as Drivers for Trained Immunity.","description":"To determine whether aorta becomes immune organ in pathologies, we performed transcriptomic analyses of six types of secretomic genes (SGs) in aorta and vascular cells and made the following findings: 1) 53.7% out of 21,306 human protein genes are classified into six secretomes, namely, canonical, caspase 1, caspase 4, exosome, Weibel-Palade body, and autophagy; 2) Atherosclerosis (AS), chronic kidney disease (CKD) and abdominal aortic aneurysm (AAA) modulate six secretomes in aortas; and Middle East Respiratory Syndrome Coronavirus (MERS-CoV, COVID-19 homologous) infected endothelial cells (ECs) and angiotensin-II (Ang-II) treated vascular smooth muscle cells (VSMCs) modulate six secretomes; 3) AS aortas upregulate T and B cell immune SGs; CKD aortas upregulate SGs for cardiac hypertrophy","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-18T12:10:14.522Z","creation":"2025-04-06T21:48:50.151Z"},"accession":"S-EPMC8934864","cross_references":{"pubmed":["35320939"],"doi":["10.3389/fimmu.2022.858256"]}}