biostudies-literatureUnknown9(2)Naghashzadeh FSARS-CoV-2 vaccines provide a safe solution with a major impact on reducing the spread of the virus and mild side effects. Research has shown rare cases of myocarditis after mRNA vaccines. This study presents a 29-year-old male with chest pain after 48 h of receiving rAd26 and rAd5 vector-based COVID-19 vaccine (Sputnik V vaccine). The electrocardiogram revealed ST-segment elevation. Also, the laboratory screening was remarkable for elevated cardiac Troponin-I level, and leukocytosis; and echocardiography depicted severe left ventricular systolic dysfunction. Overall, endomyocardial biopsy proved lymphocytic myocarditis such that the patient was successfully treated with immunosuppressive and guideline-directed medical treatment.ESC heart failure1483-1486https://www.ebi.ac.uk/biostudies/studies/S-EPMC8934948biostudies-literatureMyocarditis following rAd26 and rAd5 vector-based COVID-19 vaccine: case report.PMC8934948Naghashzadeh FDorudinia AMarjani MKashani BSShafaghi SMohamadifar ANoorali SNaji SAAmin AfalseMyocarditis following rAd26 and rAd5 vector-based COVID-19 vaccine: case report.SARS-CoV-2 vaccines provide a safe solution with a major impact on reducing the spread of the virus and mild side effects. Research has shown rare cases of myocarditis after mRNA vaccines. This study presents a 29-year-old male with chest pain after 48 h of receiving rAd26 and rAd5 vector-based COVID-19 vaccine (Sputnik V vaccine). The electrocardiogram revealed ST-segment elevation. Also, the laboratory screening was remarkable for elevated cardiac Troponin-I level, and leukocytosis; and echocardiography depicted severe left ventricular systolic dysfunction. Overall, endomyocardial biopsy proved lymphocytic myocarditis such that the patient was successfully treated with immunosuppressive and guideline-directed medical treatment.2022-01-01T00:00:00Z2022 Apr2025-04-19T13:00:32.984Z2025-04-19T13:00:32.984ZS-EPMC89349483510696710.1002/ehf2.13821