biostudies-literatureDiaz-Anton BEuropean Social FundInstituto de Salud Carlos IIIComunidad de Madrid1127-1137https://www.ebi.ac.uk/biostudies/studies/S-EPMC8934964biostudies-literatureUnknown9(2)<h4>Aims</h4>To evaluate echocardiographic and biomarker changes during chemotherapy, assess their ability to early detect and predict cardiotoxicity and to define the best time for their evaluation.<h4>Methods and results</h4>Seventy-two women with breast cancer (52 ± 9.8 years) treated with anthracyclines (26 also with trastuzumab), were evaluated for 14 months (6 echocardiograms/12 laboratory tests). We analysed: high-sensitivity cardiac troponin T, NT-proBNP, global longitudinal strain (GLS), left ventricle end-systolic volume (LVESV), left ventricle end-diastolic volume (LVEDV), and left ventricular ejection fraction (LVEF). Cardiotoxicity was defined as a reduction in LVEF>10% compared with baseline with LVEF<53%. High-sensitivity troponin T levels rose gradually reaching a maximum pESC heart failureEarly detection of anthracycline- and trastuzumab-induced cardiotoxicity: value and optimal timing of serum biomarkers and echocardiographic parameters.PMC8934964B2017/BMD‐3676PI20/01238PI15/02019AORTASANA‐CMRamirez Merino NCastellano JMMoreno-Arciniegas ALopez-Melgar BMadurga RParra Jimenez FJCiruelos EMartin-Asenjo RFernandez-Friera LSolis JZorita BDiaz-Anton BWasniewski SAmado Escanuela MGBarrio PfalseEarly detection of anthracycline- and trastuzumab-induced cardiotoxicity: value and optimal timing of serum biomarkers and echocardiographic parameters.<h4>Aims</h4>To evaluate echocardiographic and biomarker changes during chemotherapy, assess their ability to early detect and predict cardiotoxicity and to define the best time for their evaluation.<h4>Methods and results</h4>Seventy-two women with breast cancer (52 ± 9.8 years) treated with anthracyclines (26 also with trastuzumab), were evaluated for 14 months (6 echocardiograms/12 laboratory tests). We analysed: high-sensitivity cardiac troponin T, NT-proBNP, global longitudinal strain (GLS), left ventricle end-systolic volume (LVESV), left ventricle end-diastolic volume (LVEDV), and left ventricular ejection fraction (LVEF). Cardiotoxicity was defined as a reduction in LVEF>10% compared with baseline with LVEF<53%. High-sensitivity troponin T levels rose gradually reaching a maximum p2022-01-01T00:00:00Z2022 Apr2025-04-26T04:39:57.111Z2025-04-06T11:12:51.441ZS-EPMC89349643510693910.1002/ehf2.13782