{"database":"biostudies-literature","file_versions":[],"scores":null,"additional":{"omics_type":["Unknown"],"volume":["18(5)"],"submitter":["Qu K"],"pubmed_abstract":["<b>Background:</b> TET1 has been implicated in regulating inflammation and cardiovascular disease, but a newly discovered short isoform of TET1 (termed TET1s) exhibits higher expression in adult tissues than full-length TET1. However, the precise role of TET1 in cardiovascular disease remains undefined. <b>Methods and Results:</b> Based on <i>TET1<sup>-/-</sup></i> knockout mice (with deletion of both TET1 and TET1s ) and <i>TET1<sup>cs/cs</sup></i> mice (with deletion of only TET1), we found that TET1s deletion in <i>TET1<sup>-/-</sup></i> mice resulted in more serious atherosclerotic lesions in the whole aorta than TET1cs/cs in the <i>ApoE<sup>-/-</sup></i> background mice fed a high-fat diet. Atherosclerotic lesions with Oil red staining were dramatically localized in the aortic arch, a"],"journal":["International journal of biological sciences"],"pagination":["2163-2180"],"full_dataset_link":["https://www.ebi.ac.uk/biostudies/studies/S-EPMC8935216"],"repository":["biostudies-literature"],"pubmed_title":["TET1s deficiency exacerbates oscillatory shear flow-induced atherosclerosis."],"pmcid":["PMC8935216"],"pubmed_authors":["Ma Q","Qiu J","Zhang K","Wang C","Qin X","Tang C","Qu K","Wang G","Huang L","Zhong Y","Yan W","Li T","Gregersen H","Peng Q","Wang Y"],"additional_accession":[]},"is_claimable":false,"name":"TET1s deficiency exacerbates oscillatory shear flow-induced atherosclerosis.","description":"<b>Background:</b> TET1 has been implicated in regulating inflammation and cardiovascular disease, but a newly discovered short isoform of TET1 (termed TET1s) exhibits higher expression in adult tissues than full-length TET1. However, the precise role of TET1 in cardiovascular disease remains undefined. <b>Methods and Results:</b> Based on <i>TET1<sup>-/-</sup></i> knockout mice (with deletion of both TET1 and TET1s ) and <i>TET1<sup>cs/cs</sup></i> mice (with deletion of only TET1), we found that TET1s deletion in <i>TET1<sup>-/-</sup></i> mice resulted in more serious atherosclerotic lesions in the whole aorta than TET1cs/cs in the <i>ApoE<sup>-/-</sup></i> background mice fed a high-fat diet. Atherosclerotic lesions with Oil red staining were dramatically localized in the aortic arch, a","dates":{"release":"2022-01-01T00:00:00Z","publication":"2022","modification":"2025-04-26T10:11:02.385Z","creation":"2025-04-06T13:17:18.34Z"},"accession":"S-EPMC8935216","cross_references":{"pubmed":["35342333"],"doi":["10.7150/ijbs.69281"]}}