biostudies-literatureUnknown18(5)Qu KBackground: TET1 has been implicated in regulating inflammation and cardiovascular disease, but a newly discovered short isoform of TET1 (termed TET1s) exhibits higher expression in adult tissues than full-length TET1. However, the precise role of TET1 in cardiovascular disease remains undefined. Methods and Results: Based on TET1-/- knockout mice (with deletion of both TET1 and TET1s ) and TET1cs/cs mice (with deletion of only TET1), we found that TET1s deletion in TET1-/- mice resulted in more serious atherosclerotic lesions in the whole aorta than TET1cs/cs in the ApoE-/- background mice fed a high-fat diet. Atherosclerotic lesions with Oil red staining were dramatically localized in the aortic arch, aInternational journal of biological sciences2163-2180https://www.ebi.ac.uk/biostudies/studies/S-EPMC8935216biostudies-literatureTET1s deficiency exacerbates oscillatory shear flow-induced atherosclerosis.PMC8935216Ma QQiu JZhang KWang CQin XTang CQu KWang GHuang LZhong YYan WLi TGregersen HPeng QWang YfalseTET1s deficiency exacerbates oscillatory shear flow-induced atherosclerosis.Background: TET1 has been implicated in regulating inflammation and cardiovascular disease, but a newly discovered short isoform of TET1 (termed TET1s) exhibits higher expression in adult tissues than full-length TET1. However, the precise role of TET1 in cardiovascular disease remains undefined. Methods and Results: Based on TET1-/- knockout mice (with deletion of both TET1 and TET1s ) and TET1cs/cs mice (with deletion of only TET1), we found that TET1s deletion in TET1-/- mice resulted in more serious atherosclerotic lesions in the whole aorta than TET1cs/cs in the ApoE-/- background mice fed a high-fat diet. Atherosclerotic lesions with Oil red staining were dramatically localized in the aortic arch, a2022-01-01T00:00:00Z20222025-04-26T10:11:02.385Z2025-04-06T13:17:18.34ZS-EPMC89352163534233310.7150/ijbs.69281